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The National Institute of General Medical Sciences (NIGMS) primarily supports basic biomedical research that is not targeted to specific diseases or disorders. Because scientific breakthroughs often originate from such untargeted studies, NIGMS-funded work has contributed substantially to the tremendous progress that biomedical research has made in recent years. The institute's training programs help provide the most critical element of good research: well-prepared scientists.
Each year, NIGMS-supported scientists make major advances in understanding fundamental life processes. In the course of answering basic research questions, these investigators also increase our knowledge about the mechanisms involved in certain diseases. Other grantees develop important new tools and techniques, many of which have applications in the biotechnology industry. In recognition of the significance of their work, a number of NIGMS grantees have received the Nobel Prize and other high scientific honors.
NIGMS has three divisions that support research and research training in basic biomedical science fields: Cell Biology and Biophysics; Genetics and Developmental Biology; and Pharmacology, Physiology, and Biological Chemistry. The institute also has a Division of Minority Opportunities in Research, which administers programs that are designed to increase the number of minority biomedical scientists. Finally, NIGMS has a Division of Extramural Activities that handles institute grant-related functions. In addition to these divisions, the institute has a Center for Bioinformatics and Computational Biology that supports research and research training in areas that join biology with the computer sciences, engineering, mathematics, and physics.
NIGMS was established in 1962. In fiscal year 2003, its budget was $1.84 billion. The vast majority of this money funds grants to scientists at universities, medical schools, hospitals, and research institutions throughout the country. At any given time, NIGMS supports over 4,500 research grants - about 10 percent of the grants funded by NIH as a whole. NIGMS also supports 45 percent of the predoctoral trainees and about 28 percent of all the trainees who receive assistance from NIH.
The institute places great emphasis on the support of individual, investigator-initiated research grants. It funds a limited number of research center grants in selected fields, including structural genomics, trauma and burn research, and the pharmacological sciences. In addition, NIGMS funds several research contracts that provide important resources for basic scientists.
In recent years, NIGMS has launched initiatives in such cutting-edge areas as structural genomics (the Protein Structure Initiative), pharmacogenetics, collaborative research initiatives (which includes "glue grants"), and the study of complex biological systems. NIGMS is also participating in the new NIH Roadmap for Medical Research, a series of far-reaching initiatives that seek to transform the nation's biomedical research capabilities and speed the movement of research discoveries from the bench to the bedside.
NIGMS research training programs recognize the interdisciplinary nature of biomedical research today and stress approaches to biological problems that cut across disciplinary and departmental lines. Such experience prepares trainees to pursue creative research careers in a wide variety of areas.
Certain NIGMS training programs address areas in which there is a particularly serious need for well-prepared scientists. One of these, the Medical Scientist Training Program, provides investigators who can bridge the gap between basic and clinical research by supporting research training leading to the combined M.D.-Ph.D. degree. Other programs train scientists to conduct research in the rapidly growing field of biotechnology and at the interface between the fields of chemistry and biology.
NIGMS also has a Pharmacology Research Associate Program, in which postdoctoral scientists receive training in NIH or FDA laboratories and clinics.
July 16, 1958 - The Secretary, DHEW, approved establishment of the Division of General Medical Sciences.
October 17, 1962 - Congress authorized establishment of the National Institute of General Medical Sciences.
January 30, 1963 - The DHEW Secretary approved establishment of NIGMS.
October 8, 1963 - The National Advisory General Medical Sciences Council held its first meeting.
October 13, 1982 - NIGMS celebrated its 20th anniversary by establishing the DeWitt Stetten, Jr., Lecture. Dr. David S. Hogness, Stanford University, gave the first lecture.
October 1, 1989 - Administration of the Minority Biomedical Research Support Program was transferred to NIGMS from the NIH Division of Research Resources.
May 14, 2001 - NIGMS created the Center for Bioinformatics and Computational Biology.
October 17, 1962 - Public Law 87-838 authorized the Surgeon General to establish an institute to conduct and support research and research training in the general or basic medical sciences and in related natural or behavioral sciences that have significance for two or more other institutes of NIH, or that lie outside the general areas of responsibility of any other institute.
Dr. Berg became the NIGMS director in November 2003. Prior to his appointment, he directed the Institute for Basic Biomedical Sciences at The Johns Hopkins University School of Medicine in Baltimore, MD, where he also served as a professor and director of the Department of Biophysics and Biophysical Chemistry. In addition, he directed the Markey Center for Macromolecular Structure and Function and co-directed the W.M. Keck Center for the Rational Design of Biologically Active Molecules at the university.
Dr. Berg's research focuses on the structural and functional roles that metal ions, especially zinc, have in proteins. He has made major contributions to understanding how zinc-containing proteins bind to the genetic material DNA or RNA and regulate gene activity. His work, and that of others in the field, has led to the design of metal-containing proteins that control the activity of specific genes. These tailored proteins are valuable tools for basic research on gene function, and such proteins could one day have medical applications in regulating genes involved in diseases, as well. Dr. Berg has also made contributions to our understanding of systems that target proteins to specific compartments within cells and to the use of sequence databases for predicting aspects of protein structure and function.
Dr. Berg served on the faculty at Johns Hopkins from 1986-2003. Immediately before his faculty appointment, he was a postdoctoral fellow in biophysics at the university. He is the recipient of numerous awards, including a Presidential Young Investigator Award (1988-1993), the American Chemical Society Award in Pure Chemistry (1993), the Eli Lilly Award for Fundamental Research in Biology Chemistry (1995), and the Maryland Outstanding Young Scientist of the Year (1995). He also received teaching awards from both medical students and graduate students and served as an advisor to the Johns Hopkins Postdoctoral Association since its founding.
Dr. Berg received B.S. and M.S. degrees in chemistry from Stanford University in 1980 and a Ph.D. in chemistry from Harvard University in 1985. He is the coauthor of more than 100 research papers and three textbooks, Principles of Bioinorganic Chemistry, Biochemistry (5th Edition), and A Clinical Companion to Accompany Biochemistry. He also serves on the editorial boards of the journals Proteins: Structure, Function, and Genetics; Chemistry and Biology; and Current Opinion in Chemical Biology.
Division of Cell Biology and Biophysics
The Division of Cell Biology and Biophysics seeks greater understanding of the structure and function of cells, cellular components, and the biological macromolecules that make up these components. The research it supports ranges from studies of single molecules to work in structural genomics and proteomics. The long-term goal of the division is to find ways to prevent, treat, and cure diseases that result from disturbed or abnormal cellular activity.
The division has three components: the Biophysics Branch, the Cell Biology Branch, and the Structural Genomics and Proteomics Technology Branch.
This branch supports studies in the areas of biophysics, a discipline that uses techniques derived from the physical sciences to examine the structures and properties of biological substances.
Areas of emphasis in biophysical research include the determination of the structures of proteins and nucleic acids; studies of the structural features that determine macromolecular conformation; the structural analysis of macromolecular interactions and of ligand-macromolecular interactions; bioinformatics as it relates to protein and nucleic acid structure; the development of physical methodology for the analysis of molecular structure; and the development and use of theoretical methods to investigate biological systems.
Other research interests include the development and refinement of instruments needed to conduct research in the areas described above. These include nuclear magnetic resonance spectroscopy, X-ray crystallography and other scattering techniques; optical spectroscopy and other forms of microscopy. This branch also supports the development of new bioanalytical methods and biomaterials.
Cell Biology Branch
This branch supports general studies on the molecular and biochemical activities of cells and subcellular components, as well as on the role of cellular dysfunction in disease. Emphasis is placed on research with applications to more than one cell type, model system, or disease state, as well as research that does not fall within the disease-oriented mission of another NIH component.
Representative studies include those on plasma and intracellular membranes, receptors, and signal transduction mechanisms; the structure and function of the cytoskeleton; cell motility; the regulation of protein and membrane synthesis and activation of cell growth; subcellular organelles; cell division; and lipid biochemistry.
Structural Genomics and Proteomics Technology Branch
This branch supports studies that take a genomics or computational approach to determining protein structures and functions. Such research includes the development of high-throughput methods for protein structure determination, bioinformatics as it relates to the analysis of protein structures en masse, and the development of mass spectroscopy and other tools for the rapid analysis of biological molecules.
The branch is responsible for monitoring the research centers and research grants associated with the NIGMS Protein Structure Initiative (PSI). This responsibility also includes developing a database of model structures and a repository for the distribution of materials resulting from the PSI.
Division of Genetics and Developmental Biology
The Division of Genetics and Developmental Biology supports studies directed toward gaining a better understanding of the fundamental mechanisms of inheritance and development. These studies underlie the more targeted research projects supported by other NIH components. Most of the projects supported by the division make use of non-human model systems. It is expected that the results of these studies will lead to the eventual diagnosis, prevention, therapy, and cure of human genetic and developmental disorders.
Among areas under active investigation are cell growth and differentiation; chromosome organization and mechanics; control of gene expression; control of the cell cycle; developmental genetics and cell biology; extrachromosomal inheritance; mechanisms of mutagenesis; neurogenetics and the genetics of behavior; population genetics, evolution, and the genetics of complex traits; the replication, recombination, and repair of genes; and the genetics of complex systems.
Along with its research and research training activities, the Division of Genetics and Developmental Biology supports the Human Genetic Cell Repository, in which cell lines and DNA samples from people with genetic disorders and their family members, as well as somatic cell hybrids, are stored and made available for studies by scientists.
Division of Minority Opportunities in Research
The Division of Minority Opportunities in Research administers research and research training programs aimed at increasing the number of minority biomedical scientists. Support is available at the undergraduate, graduate, postdoctoral, and faculty levels, as well as for education and research infrastructure improvements.
The division has three components: the Minority Access to Research Careers (MARC) Branch, Minority Biomedical Research Support (MBRS) Branch, and Special Initiatives.
The MARC Branch offers special research training support to four-year colleges, universities, and health professional schools with substantial enrollments of such minorities as African Americans, Hispanic Americans, Native Americans (including Alaska Natives), and natives of the U.S. Pacific Islands. The branch's goals are to increase the number and competitiveness of underrepresented minorities engaged in biomedical research by strengthening the science curricula at minority-serving institutions and increasing the research training opportunities for students and faculty at these institutions.
To increase the number of researchers who are members of minority groups underrepresented in biomedical sciences, the MBRS Branch awards grants to two- or four-year colleges, universities, and health professional schools with substantial enrollments of minorities. These grants support research by faculty members, strengthen the institutions' biomedical research capabilities, and provide opportunities for students to work as part of a research team.
The division develops and launches new research and research training programs and other initiatives for minority scientists. These include the Bridges to the Future Programs (Bridges to the Baccalaureate and Bridges to the Doctorate), that are co-sponsored by the NIH National Center on Minority Health and Health Disparities.
The division is also responsible for organizing meetings and other activities that build networks among individuals and educational institutions to promote minority participation in sponsored research.
Division of Pharmacology, Physiology, and Biological Chemistry
The Division of Pharmacology, Physiology, and Biological Chemistry supports a broad spectrum of research and research training aimed at improving the molecular-level understanding of fundamental biological processes and discovering approaches to their control. Research supported by the division takes a multifaceted approach to problems in pharmacology, physiology, biochemistry, and biorelated chemistry that are either very basic in nature or that have implications for more than one disease area.
The goals of supported research include an improved understanding of drug action and mechanisms of anesthesia; pharmacogenetics and mechanisms underlying individual responses to drugs; new methods and targets for drug discovery; advances in natural products synthesis; an enhanced understanding of biological catalysis; a greater knowledge of metabolic regulation and fundamental physiological processes; and the integration and application of basic physiological, pharmacological, and biochemical research to clinical issues in anesthesia, clinical pharmacology, and trauma and burn injury. The division also supports quantitative studies of complex systems involving areas within its scope.
Biochemistry and Biorelated Chemistry Branch
This branch supports basic research in areas of biochemistry, such as enzyme catalysis and regulation, bioenergetics and redox biochemistry, and glycoconjugates. It also supports research in areas of biorelated chemistry, such as organic synthesis and methodology, as well as bioinorganic and medicinal chemistry.
Examples of biochemical investigations include studies of the chemical basis of the regulation and catalytic properties of enzymes, intermediary metabolism, the chemical and physical properties of the cellular systems for electron transport and energy transduction, and the biosynthesis and structure of carbohydrate-containing macromolecules.
Chemical investigation examples include the development of strategies for natural products synthesis, studies of the structure and function of small molecules, the chemistry of metal ions in biological systems, the development of novel medicinal agents or mimics of macromolecular function, and the creation of new synthetic methodologies.
The branch also supports studies in biotechnology. This work focuses on the development of biological catalysts, including living organisms, for the production of useful chemical compounds, medicinal or diagnostic agents, or probes of biological phenomena.
Pharmacological and Physiological Sciences Branch
This branch supports research in pharmacology, anesthesiology, and the physiological sciences. Studies range from the molecular to the organismal level, and can be clinical in nature.
In the pharmacological sciences and anesthesiology, important areas being studied are the effects of drugs on the body and the body's effects on drugs, as well as how these effects vary from individual to individual. This includes traditional investigations of the absorption, transport, distribution, metabolism, biotransformation, and excretion of drugs, as well as drug delivery strategies and determinants of bioavailability. It also includes a newer focus on pharmacogenetics, linking phenotype to genotype in drug action.
Understanding the mechanisms of drug interactions with receptors and signal transduction mechanisms is another major focus of this section. This includes studies of soluble and membrane-bound receptors and channels, secondary and tertiary messenger systems, mediator molecules, and their regulation and pharmacological manipulation.
Examples of studies in the physiological sciences include basic and clinical investigations directed toward improving understanding of the total body response to injury, including the biochemical and physiological changes induced by trauma. Research supported in this section includes studies on the etiology of post-traumatic sepsis and the mechanisms of immunosuppression, wound healing, and hypermetabolism following injury. This section also supports research in basic molecular immunobiology which focuses on using cells of the immune system to study fundamental cellular and molecular mechanisms.
Division of Extramural Activities
The Division of Extramural Activities is responsible for the grant-related activities of the institute, including the receipt, referral, and advisory council review of applications as well as grant funding and management. It maintains an overview of the institute's scientific and financial status and advises the NIGMS director and other key staff on policy matters and on the planning, development, and scientific administration of institute research and training programs. The division recommends budget allocations for the various NIGMS programs. It also acts as a liaison with other NIH components for activities relating to grant application assignments and foreign grants.
Center for Bioinformatics and Computational Biology
The Center for Bioinformatics and Computational Biology supports research and research training in areas that join biology with the computer sciences, engineering, mathematics, and physics. Toward this end, the center develops and manages programs in computational biology, such as the generation of mathematical models of biological networks, the development of modeling and simulation tools, the conduct of basic theoretical studies related to network organization and dynamic processes, and the development of methods for the analysis and dissemination of computational models. The center also defines the institute's needs for database development and applications, and it collaborates with other NIH components and Federal agencies in developing policies in this area. Other center activities include the support of multidisciplinary collaborations and of workshops, courses, and specialized meetings.
The center oversees NIH's Biomedical Information Science and Technology Initiative (BISTI) through its management of the BISTI Consortium (BISTIC). The goal of this initiative is to make optimal use of computer science and technology to address problems in biology and medicine. BISTIC is composed of senior-level representatives from the NIH institutes and centers and representatives of other Federal agencies concerned with bioinformatics and computer-based applications.
|This page was last reviewed on June 21, 2005 .|
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