![]()
Mission
Important Events in DCRT History
Biographical Sketch of DCRT Director
DCRT Programs
The Computational Bioscience and Engineering Laboratory (CBEL) provides high performance parallel supercomputing and image processing systems and leadership in the research, development, and biomedical application of massively parallel computers in a networked environment. CBEL collaborates with research investigators to model complex systems and analyze and interpret data, signals and images in computationally intensive task areas, including electron and light microscopy, x-ray crystallography and multidimensional nuclear magnetic resonance spectroscopy, molecular dynamics and quantum chemistry, drug design, protein folding, medical imaging, and radiation treatment planning.
The Laboratory of Structural Biology carries out biomolecular research using experimental approaches to directly measure forces between and within biomolecules as well as computational approaches to model and simulate biomolecular conformation and assembly. The section on molecular forces investigates the physical forces governing biomolecular function. The molecular graphics and simulation section (MGSS) develops and implements computational methods on leading edge workstations and high performance parallel platforms, with the goal of increasing the realism of simulated molecular properties. The MGSS studies macromolecular motion and interaction using molecular dynamics and quantum mechanics based methods for systems of biomedical interest. The analytical biostatistics section (ABS) develops and applies statistical-based methods to protein secondary structure prediction, structure-function prediction, and the classification of protein folds. The ABS also pioneers the application of mathematical models and statistical techniques to problems arising in endocrinology, biochemistry, and pharmacology such as the analysis of human growth data andthe modeling of drug- or hormone-receptor interactions.
The LSB develops computational methods for predicting the three-dimensional structures of proteins from primary sequences. The center for molecular modeling section provides software tools, guidance, and research collaboration in computational chemistry and structural biology.
The laboratory also develops computer programs and applications of general-purpose computers, workstations, supercomputers, and highly paralles computers for research in molecular and computational biology and chemistry.
The Physical Sciences Laboratory (PSL) brings to bear applications of mathematics and physics on a broad range of biomedical problems. Examples are the development of medical image processing methods, theories for using optical techniques in noninvasive diagnosis, studies of chemical reactions and diffusion in complex media, mathematical modeling of various aspects of cell and tissue physiology, and methods for describing macromolecular energetics.
PSL projects include an analysis of the detectibility and resolution of tumors by time-resolved optical spectrophotometry, apply a model developed in the PSL to interpret data relating to calcium absroption in bone in several diseases, and an investigation of structural transformations of clathrin-coated pits during receptor-mediated endocytosis. The laboratory serves as a general resource for collaborations involving physical sciences (e.g., crystallography, NMR spectroscopy) applied to problems of interest to medical researchers.
The Network Systems Branch provides leadership in developing and implementing networking and other communications technologies for the NIH campus and its outlying facilities, including connections with national and international data networks. The branch explores new technologies applicable to the NIH environment, provides continuous guidance and support for locally managed networks, and maintains liaisons with other DHHS components to improve the overall information dissemination infrastructure.
The Computing Facilities Branch (CFB) plans operates, and supports scientific and administrative computing resources for NIH-wide use and for use by other Federal Government agencies. CFB promotes awareness and efficient and effective use of computing resources by its customers; investigates new and emerging customer comuting requirements; and conducts research and development to identify, evaluate, and adapt new computer architectures and technologies. Services are provided on several platforms.
Mainframe computer systems support large-scale administrative applications and massive data management requirements, including the NIH administrative database and the IMPAC and CRISP systems, as well as providing a variety of batch and interactive processing capabilities.
In addition, modern relational database management systems on the mainframes provide for client-server methods to access them. Scientific computing services are provided by a general purpose scientific computer system, supplemented by a vector supercomputer and a parallel supercomputer.
The Advanced Laboratory Workstation System offers network-based support and access to a distrbuted file system for users of scientific and engineering workstations. The branch provides round-the-clock oversight for these facilities and for a wide variety of Internet and World Wide Web services. CFB services are available to users 7 days a week, 24 hours a day via high-speed point-to-point and dial connections and via the Internet.
The Customer Services Branch (CSB) furnishes centralized, integrated computer support services to DCRT customers. As the primary interface to the NIH computing community, CSB performs its liaison role by consulting with customers to resolve computing problems and provide advice referring questions to appropriate experts within DCRT operating DCRT”s computer training program and disseminating technical information, documentation, and certain software. The branch designs and develops methodologies for software change control, and it promotes NIH community awareness of DCRT services.
The Information Systems Branch (ISB) provides advice and assistance to research investigators, program officials, and administators throughout NIH in planning and obtaining data processing and computation services. ISB serves as a central resource for systems analysis, design, and programming expertise for NIH management and data processing projects related to administrative, scientific, and technical data.
The branch develops and maintains specified central NIH administrative systems and general-purpose and information handling techniques for data management and information processing. ISB plans data processing and computation projects involving DCRT central facility computers aas well as exchanges technical knowledge and operating expertise with other operations research, systems analysis, computer programming, and data processing organizations within and outside the NIH.
The Statistical Support Staff provides 1) a combination of research in mathematical statistics and computer information science with collaboration and service in all computational aspects of biomedical data analysis; 2) advice and consultation on the quantitative analysis of biomedical research data and use of the computer in such analysis, including interpreting output and developing statistical procedures when needed; 3) selection, maintenance and support of a large collection of mathematical/statistical computer systems for general use in the analysis of modeling of research data; and 4) training and teaching the effective use of these systems to biomedical researchers, administrators and other NIH users, including a rapid response to user queries.
![]() |
![]() |
![]() |
![]() |
||