|Traditional Risk Factors are Better
than Emerging Risk Factors in Predicting Heart Disease
Death in Older People with Chronic Kidney Disease
New study findings show that traditional heart disease
risk factors are more strongly associated with risk
of death from cardiovascular disease than newer, emerging
risk factors in older people with chronic kidney disease.
These results from the National Heart, Lung, and Blood
Institute-funded Cardiovascular Health Study will be
published in the April 13 issue of the Journal of the
American Medical Association.
Study participants with chronic kidney disease who
also had diabetes, systolic high blood pressure, or
left ventricular hypertrophy, or were smokers or exhibited
low physical activity had an increased risk of death
from cardiovascular causes. However, for these patients,
emerging risk factors such as elevated levels of C-reactive
protein, fibrinogen, and the blood clotting protein
factor VIIIc were not as strongly associated with greater
risk of cardiovascular death.
“The message from this study is clear: to reduce heart
disease and stroke deaths in older people with chronic
kidney disease, we need to target and control traditional
risk factors,” said Teri Manolio, M.D., Ph.D., director
of NHLBI’s Epidemiology and Biometry Program and a study
co-author. Manolio added that many proven, effective
interventions are available for reducing these risk
factors including adequate control of high blood glucose
and high blood pressure, increasing physical activity,
and stopping smoking.
Chronic kidney disease is a known, controllable risk
factor for heart disease and its incidence is on the
rise. An estimated 4.5 percent of adults have physiological
evidence of chronic kidney disease. The rate of kidney
failure in the U.S. has doubled in the past decade.
Chronic kidney disease was defined in the study by an
estimated glomerular filtration rate (GFR) of less than
60ml/min/1.732, a measure of how well the kidneys are
filtering waste from blood. The study defined cardiovascular
mortality as death from heart disease, heart failure,
peripheral vascular disease, and stroke.
The Cardiovascular Health Study is a longitudinal study
of traditional and emerging risk factors for death from
cardiovascular diseases in over 5,800 men and women
over the age of 65 in four U.S. communities: Forsyth
County, NC; Sacramento County, CA; Washington County,
MD; and Pittsburgh, PA. Participants were followed for
an average of 8.6 years.
Dr. Manolio is available to comment on these and other
study findings. To schedule an interview, please call
the NHLBI Communications Office at (301) 496-4236 or
email at email@example.com.
For more information about chronic kidney disease,
visit the National Institute of Diabetes and Digestive
and Kidney Diseases at www.niddk.nih.gov.
NHLBI is part of the National Institutes of Health
(NIH), the Federal Government's primary agency for
biomedical and behavioral research. NIH is a component
of the U.S. Department of Health and Human Services.
Additional information about cardiovascular disease
and NHLBI-supported research and educational programs
are available online at the NHLBI website, www.nhlbi.nih.gov.