NIH News Release
NATIONAL INSTITUTES OF HEALTH
Office of the Director

Office of Medical Applications of Research


FOR IMMEDIATE RELEASE
Friday, August 18, 2000
Contacts: John Bowersox (OMAR)
(301) 496-4819
bowersoj@od.nih.gov

Robert Bock (NICHD)
(301) 496-5133
bockr@mail.nih.gov

NIH Consensus Development Conference Reaffirms Single Course
of Antenatal Corticosteroids for Preterm Women; Cites Insufficient Evidence for Repeat Courses

A consensus panel convened by the National Institutes of Health today reaffirmed the importance of single-course treatment with corticosteroids for pregnant women at risk for pre-term delivery. However, the panel concluded that current data do not support the routine use of repeat courses of this treatment.

Corticosteroids are hormones produced by the adrenal gland. Synthesized corticosteroids, when given to pregnant women, accelerate the maturation of specific organs, including the lungs, in the fetus.

In 1994, virtually the same panel that met today concluded, in part, that single course administration of corticosteroids to pregnant women at risk for preterm delivery reduces the risk of death, respiratory distress syndrome, and brain hemorrhage in their preterm infants. The 1994 panel noted, however, that the potential benefits and risks of administering more than one course of antenatal corticosteroids during a pregnancy were unknown and called for additional research on this issue.

The panel reconvened on August 17 and 18, 2000 at the Bethesda, MD campus of the NIH for the consensus conference titled Antenatal Corticosteriods Revisited: Repeat Courses. The conference was sponsored by the National Institute of Child Health and Human Development and the NIH Office of Medical Applications of Research. Cosponsors included the National Institute of Nursing Research and the National Heart, Lung, and Blood Institute.

"In recent years, our recommendation for administering corticosteroids to pregnant women at high risk for pre-term delivery has been widely adopted," said panel chair Larry Gilstrap, M.D., of the University of Texas-Houston Medical School. "However, there is increasing evidence that clinicians are administering repeat courses of corticosteroids."

The 16-member panel concluded the current data are insufficient to support the routine use of repeat courses of antenatal corticosteroids. In reviewing the public presentations and published literature, they noted that there are potential benefits and risks of repeat courses. In terms of benefits, some studies of limited quality suggest a reduction of respiratory distress syndrome and patent ductus arteriosis, an abnormality of the vascular system. In terms of risks, some studies suggest an increase in psychomotor delay and in behavioral problems. The effect of repeat versus single course steroids on neonatal mortality is also unknown.

In reaffirming their 1994 recommendation, the panel stated that all pregnant women between 24 and 34 weeks of gestation, at risk of preterm delivery within seven days, should be considered for single course antenatal corticosteroid treatment. In today's statement they recommended that repeat courses of antenatal corticosteroids should be reserved for patients enrolled in randomized controlled studies. However, they emphasized that the design of these studies should minimize the exposure of mothers and their fetuses to corticosteroids. Moreover, they called for studies to assess the effects of repeat courses of corticosteroids on fetal and postnatal growth as well as on long-term effects on growth and neuropsychological development.


The full NIH Consensus Statement on Antenatal Corticosteroids Revisited: Repeat Courses is available by calling 1-888-NIH-CONSENSUS (1-888-644-2667) or by visiting the NIH Consensus Development Program Web site at http://consensus.nih.gov.

The NIH Consensus Development Program was established in 1977 to resolve in an unbiased manner controversial topics in medicine. To date, NIH has conducted 112 such conferences addressing a wide range of controversial medical issues important to health care providers, patients, and the general public.

NOTE TO RADIO EDITORS: An audio report of the conference results will be available after 4 p.m. August 18, 2000 from the NIH Radio News Service by calling 1-800-MED-DIAL (1-800-633-3425).