Scientists Estimate Probability of Death From Breast Cancer and Other Causes Following Diagnosis
Women who are diagnosed with breast cancer at a young age, or at
an advanced stage at any age, are more likely to die from the disease
than from all other causes of death combined, according to a new
study by scientists at the National Cancer Institute (NCI), part
of the National Institutes of Health. In the September 1 issue of
the Journal of the National Cancer Institute*,
the NCI researchers report that the probability of death from breast
cancer varies greatly according to stage, tumor size, estrogen receptor
(ER) status**, and age at diagnosis in both blacks
“To our knowledge, this study is the first comprehensive
risk analysis to examine in detail both the risk of death from breast
cancer and other causes following a breast cancer diagnosis,”
said Catherine Schairer, Ph.D., the study’s lead author and
an epidemiologist in the Division of Cancer Epidemiology and Genetics
at NCI. “These results can provide important prognostic information
to physicians and patients, and may help in weighing the risks and
benefits of various treatment options.”
To calculate the probabilities of death from breast cancer vs.
all other causes combined among breast cancer patients, Schairer
and her colleagues analyzed data from NCI’s Surveillance,
Epidemiology and End Results (SEER) Program for more than 400,000
breast cancer patients diagnosed between 1973 and 2000. They computed
probabilities of death from breast cancer and all other causes combined
over a 28-year follow-up period according to stage and age at diagnosis,
and over an 11-year follow-up period according to tumor size and
ER status for a subset of cases.
The researchers found that breast cancer patients with ER-negative
tumors were more likely to die from their cancer than those patients
with ER-positive tumors, and that patients with larger tumors were
more likely to die from their cancer than patients with smaller
For patients diagnosed with localized breast cancer (cancer that
has not spread past the breast tissue) before age 50, the probability
of death from breast cancer was greater than that from all other
causes. The authors found the same to be true for patients diagnosed
with regional disease before age 60, or with distant disease (cancer
that has spread to distant organs or distant lymph nodes) at any
As the age at breast cancer diagnosis increased, the risk of death
from other causes increased and the risk of death from breast cancer
generally decreased. However, even among older patients, death from
breast cancer still accounted for a significant portion of mortality.
The researchers also found that while the probability of death
from breast cancer varied greatly according to stage, tumor size,
ER status, and age at diagnosis in both blacks and whites, mortality
from breast cancer and other causes was generally higher in blacks
than in whites even after accounting for these factors. The scientists
write that these results are consistent with those of other analyses
that have shown generally poorer breast cancer survival in black
patients than in white patients. The NCI researchers suggest, as
have other researchers, that this higher probability seen in blacks
may be due to differences in treatment and to a higher prevalence
of obesity and obesity-related health conditions in black patients,
among other factors.
“Understanding these probabilities of death from breast cancer
based on stage, tumor size, ER status and age can provide useful
information for patients and physicians alike” said Schairer.
“Future studies, such as similar analyses for other cancers
and more in-depth analyses for breast cancer according to tumor
size and hormone receptor status, could generate additional valuable
tools for physicians and patients.”
For more information about cancer, please visit the NCI Web site
or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).
* Schairer C, Mink, PJ, Caroll L, and Devesa SS. “Probabilities
of death from breast cancer and other causes among female breast cancer
patients.” Journal of the National Cancer Institute,
Sept. 1, 2004; vol. 96 (17):1311-21.
** An estrogen receptor, found on some cancer cells, is a protein
to which estrogen binds. Cancer cells with this protein are considered
ER-positive, and breast cancer cells that are ER-positive require
the hormone estrogen to grow. These cancer cells will usually respond
to hormone (antiestrogen) therapy that blocks these receptor sites.
Conversely, breast cancer cells that do not have a protein, or receptor
molecule, to which estrogen will attach are called ER-negative cells.
These cells do not need the hormone estrogen to grow and usually
do not respond to antiestrogen therapy.