|FOR IMMEDIATE RELEASE
Thursday, March 7, 2002
Contact: Diana K. Carroll|
New Awards, Expanded Focus for Pediatric AIDS Clinical Trials Group
- Perinatal Transmission: continue studying the safety of antiretroviral drugs in HIV-infected pregnant women; continue translational research for resource-poor international partners; and examine why current interventions are not fully successful.
- Pediatric Treatment: study the safety of new drugs, the best use of available drugs and treatment management; and evaluate the effect of interventions on the course of the disease.
- Adolescent Treatment: expand adolescent research to every PACTG site; study the effects of treatment on acute and early infection and on restoration of immune function; and promote collaborations to assist in prevention research, including behavioral research.
- Long-Term Evaluation of Antiretroviral Therapies: increase commitment to long-term pediatric studies; study drug safety in infants who escape infection and in children who become infected; and link durability of treatment responses to clinical outcomes.
- Domestic and International Collaborations: collaborate with other NIH-sponsored domestic and international HIV/AIDS therapeutic and prevention trials networks; encourage scientific exchange and resource-sharing with international partners; and conduct international studies of interventions that can be readily transferred to developing countries.
1 Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report: Midyear Edition, 13(1), June 2001.
2 UNAIDS. Report on the Global HIV/AIDS Epidemic: December 2001.
Before the PACTG was established, clinical studies of HIV-positive mothers, children and adolescents were carried out and funded through NIAID's AIDS Clinical Trials Group (ACTG). In 1995, an independent review panel recommended the PACTG become a separate entity from the ACTG. The PACTG was established as an independent network in 1997 and now comprises 18 Pediatric AIDS Clinical Trials Units funded by NIAID, and 35 domestic and international sites funded by the National Institute of Child Health and Human Development. To date, the PACTG has initiated 113 clinical trials and, as of December 2001, has enrolled approximately 27,432 women and children. Some noteworthy studies and findings include:
- The landmark study showing that AZT given to HIV-positive pregnant women and their newborns shortly after birth can greatly reduce the rate of HIV transmission (ACTG 076).
- Long-term follow-up studies of infected and uninfected but antiretroviral-exposed infants.
- Studies demonstrating that multi-agent combination treatment of HIV-infected pregnant women can lead to very low rates of HIV transmission to their infants.
- Numerous studies in HIV-infected women and children to determine appropriate doses of antiretrovirals and other drugs in these populations.
- Studies evaluating the use of highly active antiretroviral combinations in children, which contributed to establishing the standard of care for antiretroviral therapy in children.
- Research evaluating the restoration of immune responses after initiation of potent combination therapies.
- Studies elucidating the differences in the pathogenesis of acute HIV infection in infants compared with infection acquired by adolescents or adults.
For more information on pediatric or adult clinical trials, contact the AIDS Clinical Trials Information Service at 1-800-TRIALS-A (1-800-874-2572), 12 p.m. to 5 p.m. Eastern Time, Monday through Friday. Bilingual health specialists are available. You can also visit their Web site at http://www.actis.org.
Pediatric AIDS Clinical Trials Units and Principal Investigators
University of Alabama at Birmingham
Robert Pass, M.D.
University of California at Los Angeles
School of Medicine
Yvonne J. Bryson, M.D.
University of California at San Diego
Stephen A. Spector, M.D.
University of California at San Francisco
Diane W. Wara, M.D.
University of Miami School of Medicine
Gwendolyn B. Scott, M.D.
Children's Memorial Hospital/Chicago
Ram Yogev, M.D.
Tulane University Medical School/New Orleans
Russell Van Dyke, M.D.
Johns Hopkins University School of
Public Health and Hygiene/Baltimore
Andrea Ruff, M.D.
Kenneth McIntosh, M.D.
University of Massachusetts Medical School/Worchester
Katherine F. Luzuriaga, M.D.
UMDNJ-New Jersey Medical School/Newark
Paul Palumbo, M.D.
Bronx-Lebanon Hospital Center
Saroj Bakshi, M.D.
Columbia University College of
Physicians and Surgeons
Columbia Presbyterian Medical Center/New York City
Anne A. Gershon, M.D.
Duke University Medical Center/Durham
Ross McKinney, Jr., M.D.
Children's Hospital of Philadelphia
Stuart E. Starr, M.D.
University of Puerto Rico
Pediatric Hospital/San Juan
Irma Febo, M.D.
St. Jude Children's Research Hospital/Memphis
Patricia Flynn, M.D.
Texas Children's Hospital/Houston
William T. Shearer, M.D., Ph.D.
Statistical and Data Management Center
Harvard School of Public Health
Michael D. Hughes, Ph.D.
Coordinating and Research Operations Center|
Social & Scientific Systems, Inc.
Steven A. Spector, M.D.
NIAID is a component of the National Institutes of Health (NIH). NIAID supports basic and applied research to prevent, diagnose, and treat infectious and immune-mediated illnesses, including HIV/AIDS and other sexually transmitted diseases, illness from potential agents of bioterrorism, tuberculosis, malaria, autoimmune disorders, asthma and allergies.
Press releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.
The National Institute of Allergy and Infectious Diseases is a component of the National Institutes of Health, U.S. Department of Health and Human Services.