NCI Press Office
Production of these compounds is one part of the process that must take place over the next several months. At this time, it is not possible to produce the large quantities of endostatin or angiostatin necessary for human trials. NCI is working with Entremed, Inc., on production issues for endostatin and with Bristol-Myers Squibb Co., on production issues for angiostatin.
It is very important to emphasize that while the possibilities raised by these studies in mice are encouraging, it is not known whether endostatin or angiostatin will be effective in people with cancer.
Clinical trials of other anti-angiogenesis agents are under way both by individual drug companies and by NCI. Patients interested in information about ongoing trials listed in NCI's PDQ database can contact the NCI's Cancer Information Service at 1-800-4-CANCER or PDQ themselves via the Internet (http://cancertrials.nci.nih.gov -- under "more" choose Introduction, then choose "finding specific trials.")