NCI Launches New Integrative Cancer Biology Program
The National Cancer Institute (NCI), part of the National Institutes
of Health (NIH), announced $14.9 million in funding for a new Integrative
Cancer Biology Program (ICBP). The ICBP is a unique initiative designed
to gain new insights into the development and progression of cancer
through a systems-wide approach. An integrative and multi-disciplinary
effort among all fields of cancer research will be applied, incorporating
a spectrum of new technologies such as genomics, proteomics, and
molecular imaging, to generate computer and mathematical models
that could predict the cancer process.
The ICBP initiative highlights nine integrative biology centers.
These centers will provide the nucleus for the design and validation
of computational and mathematical cancer models. The models will
simulate complex cancer processes, and will be used to address all
stages of cancer, from the basic cellular processes through tumor
growth and metastasis. "The key aspect that sets the ICBP effort
apart from others," said Daniel Gallahan, Ph.D., Associate Director,
Division of Cancer Biology, NCI, "is the focus on building predictive
cancer models, and not just analyzing data."
The ICBP centers also will serve as training and outreach programs,
enabling developing technologies to be communicated to other scientists
in the cancer research community. This outreach effort adds another
level of integration, and also provides the means for other scientists
to validate the usefulness of these models.
The new ICBP centers represent a broad spectrum of cancer research.
The centers and the principal investigators are:
- Thomas Deisboeck, M.D., Massachusetts General Hospital, Boston,
"Development of a Virtual Tumor"
- Todd Golub, M.D., Dana-Farber Cancer Institute, Boston, Mass.
"Signatures of Kinase Activation in Cancer"
- Joe W. Gray, Ph.D., Lawrence Berkeley National Laboratory, Berkeley,
"Systems-Based Predictions of Response to Cancer Therapy"
- Tim H-M Huang, Ph.D., Ohio State University, Columbus, Ohio.
"Interrogating Epigenetic Changes in Cancer Genomes"
- Richard Hynes, Ph.D., Massachusetts Institute of Technology,
"Regulatory Networks in Cancer Initiation and Progression"
- Timothy Kinsella, M.D., University Hospital of Cleveland, Cleveland,
"Complex Systems and Control of MMR-Deficient Cells"
- Joseph Nevins, Ph.D., Duke University, Durham, N.C.
"Integration of Oncogenic Networks in Cancer Phenotypes"
- Sylvia Plevritis, Ph.D., Stanford University School of Medicine,
"Computational Modeling of Cancer Biology"
- Vito Quaranta, M.D., Vanderbilt University Medical Center, Nashville,
"Multiscale Mathematical Modeling of Cancer Invasion"
The ICBP centers also will interact and collaborate with other
NCI programs and external groups. NCI’s Cancer Biomedical
Information Grid (caBIG) program will coordinate all the bioinformatics
software needed by the ICBP as part of caBIG’s ongoing effort
to simplify and integrate the sharing and usage of data by providing
access to NCI’s cancer research communities.
For more information about the cancer Biomedical Information Grid,
visit the caBIG web site at http://cabig.nci.nih.gov/
For more information about cancer, visit the NCI Web site at
http://www.cancer.gov or call
NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).