Mouse DNA to Aid Biomedical Research
Will Help Discover Why Some People Are Susceptible
to Certain Diseases
Researchers have successfully sequenced the DNA of 15
mouse strains most commonly used in biomedical research.
More than 8.3 million genetic variations, or single nucleotide
polymorphisms (SNPs), were discovered among the genomes
of the 15 mouse strains, and the data are now available
on a public website. These new data on laboratory mice
will help researchers better understand what makes some
individuals more susceptible than others to certain diseases,
and will serve as a valuable resource as researchers determine
the role that various environmental substances may play
in the development of disease.
The “Resequencing and SNP Discovery Project” led by the
National Institute of Environmental Health Sciences (NIEHS),
part of the National Institutes of Health, and its National
Toxicology Program, began less than two years ago with
a $13 million budget. The work was completed by Perlegen
Sciences, Inc. and the data are available on the National
Center for Biotechnology Information website at http://www.ncbi.nlm.nih.gov/SNP/.
||David A. Schwartz, M.D., Director,
National Institute of Environmental Health Sciences and National
Kelly Frazer, Ph.D., Vice President of Genomics
Perlegen Sciences, Inc.
David Threadgill, Ph.D., Associate Professor,
Department of Genetics University of North Carolina
David Christiani, M.D., Professor of Occupational
Medicine and Epidemiology, Environmental Health and Epidemiology,
Harvard School of Public Health
||Teleconference with NIEHS Director and leading
|| Wednesday, October 25, 1:00 p.m. EDT
||Teleconference call, to dial in call: 877-707-9631
International Reporters, call 785-832-0301
Reporters please call Robin Mackar, 919-541-0073, to reserve your phone
line or for further assistance.
The National Institutes of Health (NIH) — The Nation's Medical
Research Agency — includes 27 Institutes and Centers and
is a component of the U.S. Department of Health and Human Services.
It is the primary federal agency for conducting and supporting basic,
clinical and translational medical research, and it investigates the
causes, treatments, and cures for both common and rare diseases. For
more information about NIH and its programs, visit www.nih.gov.