Second Gene Linked to Familial Testicular Cancer – 2
Narrator: This is NIH Health Matters. A new study shows that specific variations or mutations in a particular gene can raise a manís risk of familial, or inherited, testicular germ-cell cancer. Dr. Constantine Stratakis is with the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
Dr. Stratakis: So the key finding here is that we found inactivating mutations in a gene that regulates cyclic AMP levels. Cyclic AMP mediates the affects of many of the hormones that regulate testicular function.
Narrator: Dr. Stratakis says Cyclic AMP is one of the most ancient signaling pathways that regulates how cells respond to hormones. For more information, visit www.nih.gov. Health Matters is produced by the National Institutes of Health, part of the US Department of Health and Human Services.
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