NIH-Supported Study Finds Novel Pathway May Open Doors for New Blood Pressure Treatments – 2
Narrator: This is NIH Health Matters. I’m Joe Balintfy. Researchers have found that enzymes play an important role in the management of high blood pressure.
Zeldin: Cytochrome P450 have traditionally been known to be involved in the metabolism of drugs and carcinogens.
Narrator: Dr. Darryl Zeldin at the National Institute of Environmental Health Sciences says they are major detoxifying enzymes in the body.
Zeldin: These enzymes can also be involved in the metabolism of endogenous fatty acids to compounds called EETs—that have potent effects on the cardiovascular system.
Narrator: He explains, a study showed mice genetically engineered to have high levels of Cytochrome P450 did not develop high blood pressure. For details, visit www.niehs.nih.gov. Health Matters is produced by the National Institutes of Health, part of the U.S. Department of Health and Human Services.
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