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Breast Cancer Stem Cells May Be Key to Multi-drug Resistance – 2

Narrator: This is NIH Health Matters. When cells in breast cancer tumors stop responding to drugs, it’s called multi-drug resistance. Dr. Michael Gottesman, director of clinical research at the National Cancer Institute explains that cancer stem cells may cause that resistance.

Dr. Gottesman: The basis for that resistance is a residual group of cells within the tumor that have been called cancer stem cells.

Narrator: Dr. Gottesman is leading a study that examines breast cancer stem cells.

Dr. Gottesman: Our original idea was to look at those cells and ask whether they expressed some of the markers associated with drug resistance, and indeed they do.

Narrator: For more information on breast cancer stem cells and multi-drug resistance, visit www.cancer.gov. Health Matters is produced by the National Institutes of Health, part of the U.S. Department of Health and Human Services.

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This page last reviewed on March 14, 2011

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