Blood Stem-Cell Transplant Regimen Reverses Sickle Cell Disease in Adults – 1
Narrator: This is NIH Health Matters. Sickle cell disease affects hemoglobin, thatís the molecule in red blood cells that caries oxygen throughout the body. People with this disorder have unusual hemoglobin molecules which can distort red blood cells into a sickle, or crescent, shape. Dr. John Tisdale at the NIH Molecular and Clinical Hematology Branch says a new blood stem-cell transplant approach has effectively reversed sickle cell disease.
Dr. Tisdale: What we did was to take an approach to bone marrow transplant that would allow us to do it in very sick adults.
Narrator: A previous blood stem-cell transplantation approach using chemotherapy has successfully cured children of sickle cell disease, but it is too toxic for adults. For more information, visit www.niddk.nih.gov. Health Matters is produced by the National Institutes of Health, part of the U.S. Department of Health and Human Services.
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