Blockade of learning and memory genes in Alzheimer’s disease – 1
Narrator: This is NIH Health Matters. I’m Joe Balintfy. Reduced gene activity in the brain appears to be an early event affecting people with Alzheimer's disease.
Corriveau: The gene is called HDAC2.
Narrator: Dr. Roderick Corriveau at the NIH says HDAC2 is known to tighten up spools of DNA.
Courriveau: Think of this string of holiday lights that has been put in a box and the end of a holiday season and it's all bundled up in that box. In fact it's a ball and it's all tightly wound together. This tangled ball represents the genetic tools for making new memories and the unusable state that we find them in, in Alzheimer's disease.
Narrator: For information on this study, visit www.ninds.nih.gov. Health Matters is produced by the NIH, part of the U.S. Department of Health and Human Services.
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