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Much Touted “Depression Risk Gene” May Not Add to Risk After All – 3

Narrator: This is NIH Health Matters. A range of factors led to the wide acclaim of a 2003 study suggesting a possible gene-environment interaction that contributes to depression risk. However, despite considerable research building upon the study, attempts to replicate its findings—a key step in the scientific process—has had inconsistent results. Now according to a new study, funded by the National Institute of Mental Health and published in a recent issue of the Journal of the American Medical Association, a gene long thought to increase a person’s risk for major depression actually may have no effect at all. For more information about depression risk studies, visit www.nimh.nih.gov. Health Matters is produced by the National Institutes of Health, part of the US Department of Health and Human Services.

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This page last reviewed on March 24, 2011

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