Trans-NIH Mouse Initiative
*Funding Opportunitites


RFA on Targeted Mutations to Study Ethanol-Related Behaviors

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) is soliciting proposals to use targeted gene disruption and overexpression techniques in mice to elucidate the roles of specific neuronal proteins in mediating the effects of ethanol on brain function and behavior. To be considered responsive to this RFA, applications must propose elucidation of the relationship between ethanol's effects on a specific aspect of nervous system function and a specific behavioral effect of ethanol. NIAAA strongly encourages mouse geneticists with expertise in targeted mutagenesis techniques to seek collaborations with established alcohol researchers, in order to bring these powerful approaches to bear on the elucidation of the mechanisms of alcohol's effects on behavior. Applications proposing creation of strains of mice bearing new targeted mutations or overexpressed transgenes, and applications proposing use of previously existing targeted mutations or overexpressed transgenes will all be considered responsive to this RFA.

This RFA will use the R01 and R21 grant mechanisms. R01 grants may have a duration of up to 5 years. While there is no limit on their budget, investigators requesting more than $500,000 direct costs in any budget year must obtain permission from NIAAA before submitting such a proposal. R21 grants may have a duration of up to 3 years, and a maximum budget of $100,000 direct costs per year. NIAAA anticipates making approximately 8 awards. Letters of intent are due on April 5, 2000, and applications are due on May 5, 2000.

The full text of this RFA can be found at