Trans-NIH Mouse Initiative


The Mouse UniGene Collection

Expressed sequence tag (EST) approaches have been used in several organisms as a cost-effective means of identifying a remarkable number of novel genes. In the mouse, over 400,000 EST sequences have been generated, primarily through an initiative funded by the Howard Hugues Medical Institute and carried out at the Washington University Genome Sequencing Center. The Mouse UniGene collection is an attempt to partition these ESTs into sets or "clusters" that correspond to distinct mouse genes. The reduced accuracy and partial nature of ESTs makes this a challenging task, but methods have been developed to generate UniGene in a mostly automated fashion. The UniGene set has proven useful for the selection of candidates for high-throughput gene mapping and gene expression studies.

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