COMMENTS ON

E-biomed: A Proposal for Electronic Publications in the Biomedical Sciences (May 5, 1999 DRAFT)

Go to: [E-biomed comments index] [Link disclaimer]

July 5 - July 11, 1999

July 11, 1999

Stevan Harnad, University of Southampton, July 11, 1999

On Fri, 9 Jul 1999 mloeb wrote:

> Stevan,
>
> I'm touching base with you to review what you plan to say during your
> talk at the upcoming CESSE conference in Cleveland. You and I are the
> only speakers in the session. We are suppossed to be talking about the
> future economics of journal publishing... looks like a perfect
> opportunity to expose our respective visions on the future of
> scholarly publishing in general.
>
> Have you thought about what you will say? I'd like to know so that I
> can complement/challenge your points, and then we can have a
> constructive, facilitated discussion/exchange with the audience for the
> balance of the session.
>
> Let me know your thoughts; I'll share with you mine.
>
> Look forward to meeting/seeing you in Cleveland.
>
> regards,
> Matt Loeb
> publisher
> ieee computer society

http://www.cesse.org/cesse99/program.htm

Hi Matt,

Nice to hear from you. I know (since it has been explicitly denied!) that this is to be something of a roast of me and my views, and that's fine!

Here they are (the details are in my published and posted writings, probably the two in Nature and Nature-online, below, tell it all as well as anything):

(1) I am speaking ONLY about refereed journal articles, not books or magazines.

http://www.cogsci.soton.ac.uk/~harnad/THES/thes.html

(2) Unlike all other literature, their authors write these papers to report their ideas and findings, not to make money on their texts. All they want is to reach the eyes and minds of a maximum of fellow researchers, present and future, once their findings have passed peer review.

http://www.cogsci.soton.ac.uk/~harnad/nature2.html

(3) They accordingly give them away for free to their publishers, and, after peer review, give away free reprints to all requesters.

http://amsci-forum.amsci.org/archives/september-forum.html

(4) Online self-archiving now makes it possible for them to give away their refereed reprints to one and all forever on the broadest possible scale.

http://www.arl.org/scomm/subversive/toc.html

(5) Publishers should in no way to attempt to prevent free self-archiving by authors by trying to forbid it in copyright agreements. This is the eye of the storm. See:

http://www.cogsci.soton.ac.uk/~harnad/science.html

(6) The American Physical Society has already provided a model copyright policy: Authors may self-archive both the unrefereed preprint and the refereed reprint for free for all. The Publisher retains all rights to SELL either the paper or online version of the journal.

http://www.cogsci.soton.ac.uk/~harnad/Hypermail/Author.Eprint.Archives/0006.html

(7) The effect of online author self-archiving will be a transition of the reader/user community to the free online versions.

http://xxx.lanl.gov/cgi-bin/show_monthly_submissions
http://xxx.lanl.gov/cgi-bin/show_weekly_graph

(8) Eventually this will produce cancelation pressure (although it has not done so yet in Physics, where it is most advanced). If/when it does, my prediction is that publishers will have to restructure and down-size so as to provide only the service of quality control and certification [peer review, editing, tagging as accepted by Journal X].

http://www.cogsci.soton.ac.uk/~harnad/nature.html

(9) The much reduced cost of providing solely this service will be recoverable from author-institution publication charges, which will in turn be recoverable from institutional savings from cancelling Subscription/Site-License/Pay-Per-View (S/L/P).

(10) The critical difference is that reader-institution-end payment (S/L/P) is access-blocking, whereas author-institution-end payment is not. But as long as author self-archiving rights are guaranteed (5,6), the market can decide whether or not S/L/P can survive alongside it (and how long).

(11) The infrastructure for self-archiving is emerging as we speak, led by Los Alamos, soon to be followed by E-bionet, and then all the other disciplines.

http://xxx.lanl.gov/
http://www.nih.gov/welcome/director/ebiomed/ebiomed.htm
http://library.caltech.edu/publications/ScholarsForum/
http://cogprints.soton.ac.uk/

The self-archiving initiative in this very special subdomain of literature -- the give-away refreed research literature -- is unstoppable, because ethics, prgamatics, and logic, as well as the inherent interests of research itself and hence of all of society, are all behind it. Its progress can only be slowed temporarily by playing on confusions and uncertainties in people's minds, simply because it is all so new and they have not yet thought it through. It would be to publishers' long-term advantage to try to see ahead rather and restructure accordingly, rather than to try to hold the literature hostage to the status quo. They must come to terms with what it in the best interests of research and researchers in the new online world, and design a new niche for themselves in the PostGutenberg Galaxy.

A tide-over consortial subsidy out of windfall S/L/P savings to smooth the transition from reader-institution-end cost-recovery via S/L/P to author-institution-end cost-recovery via quality-control/certification charges would be worth planning out with the library-institution and research-funding community in advance.

HTTP://AMSCI-FORUM.AMSCI.ORG/scripts/wa.exe?A1=ind98&L=september-forum&F=lf#26

Cheers,
Stevan Harnad
Professor of Cognitive Science
Department of Electronics and Computer Science
University of Southampton
UNITED KINGDOM http://www.cogsci.soton.ac.uk/~harnad/
http://www.princeton.edu/~harnad/
ftp://ftp.princeton.edu/pub/harnad/


July 10, 1999

Stevan Harnad, University of Southampton, July 10, 1999

On Sat, 10 Jul 1999, Hal Varian wrote:

> Undoubtedly, [trade authors] would be happy to be paid for
> writing, but academic authors would be happy to be paid for their writing
> too.

I'm afraid I have to disagree. The answer is "yes" when the academic authors are wearing their trade hats (writing books or magazine articles) but the answer is "no" when they are reporting their research in peer-reviewed journals.

> No author *wants* to deter eyeballs, even trade authors.

You might as well say no producer of any product wants to deter greater consumption of their product (it's just that they would like to get paid for it!).

> If academic authors
> were *sufficiently* compensated for detering eyeballs, I expect many would
> be happy to do so. If a referred journal offered you payment for an
> article, would you turn it down? (Several refereed journals in business
> and medicine do pay for articles, by the way.)

I'm afraid I have to disagree again: It would require a MONSTROUSLY large amount of money to make a research author trade off his potential impact on research for the impact on his pocketbook. (And many scientists and scholars, still recalling why they chose the leaner path of Learned Inquiry rather than heading straight for the junk bond market in the first place, would decline even that!)

But no peer reviewed journal could (or would) afford to make it worth an author's while anyway.

Here's a test: How much would (should) the author of a refereed journal article accept to SELL his self-archiving rights to his publisher?

(My guess: a lot more than any publisher could ever afford to offer! This is not big-market literature we're talking about! And that's the point!)

http://www.cogsci.soton.ac.uk/~harnad/THES/thes.html

> Furthermore, even academic authors make money from their publications,
> albeit indirectly. If you regress earnings on publications and citations
> you find a large and significant coefficient on refereed journal
> publications and citations. Academic authors who publish more are paid
> more, and part of the motivation for academic publishing is the prospect
> of academic advancement and higher salaries.

Correct, but TOTALLY irrelevant! The author is not being paid out of the access-blocking toll-gate receipts from the sale of his papers by S/L/P!

On the contrary, if you properly regressed THOSE on earnings, you would find that they REDUCE impact and hence earnings!

This is a completely spurious, noncausal correlation, and the simple act of self-archiving shows it to be so. (Have the 100,000 authors who have self-archived in Los Alamos reduced or inhanced their impacts and incomes?)

http://xxx.lanl.gov/cgi-bin/show_monthly_submissions

> The point of my note is that motivations are not as far apart as you
> claim: there is an (indirect) financial motivation in publication for
> academic authors and there is a large component of desire to communicate
> in trade authors. There is certainly a difference in the economic model
> in the two industries, but the divide in the motivations of the authors is
> not as "profound and significant" as you claim.
>
> But again, I don't think this point makes much difference for the rest of
> your argument.

I'm afraid I disagree, and I do think it makes a great difference. The similarities between the two populations are partial, superficial and, in the present context, misleading. The deep differences are in the means/ends: For most trade authors, self-archiving their work free for all is only a temporary means to an end (hopeful, eventual compensation); for (most?) refereed journal authors it IS the end (widest possible access to their findings for peer eyes/mind, present and future).

The reason stressing the similarities between the trade and nontrade literatures here is misleading is that the self-archiving model I have been advocating for refereed journal papers is decidedly NOT the right model for the rest of the literature, and conflating the two simply blurs the critical insight at the core of all this.

But this can be settled empirically: Let a line be drawn in Cyberspace, and let those who are interested in giving away their products (whatever they are) as freebies in perpetuo step to the left of it (say), and let those who are not step to the right.

The entire refereed journal authorship will be on the left. Perhaps some others will be too. Let's see wait and see who. I'm predicting that most book and magazine authors will not (and note that I said "in perpetuo," not in "pro-tem promo"!).

In any case, that is the literature I am dedicated to freeing (from its hostagehood to the trade model and S/L/P) -- not every product of the human mind!

Stevan Harnad
Professor of Cognitive Science
Department of Electronics and Computer Science
University of Southampton
UNITED KINGDOM
http://www.cogsci.soton.ac.uk/~harnad/
http://www.princeton.edu/~harnad/
ftp://ftp.princeton.edu/pub/harnad/


July 9, 1999

Mark H. Miller, M.D., July 9, 1999

Dr. Varmus, Suffice it to say that I am in strong agreement with the comments of Dr. Relman in his recent NEJM editorial statement about E-Biomed. Please do not confuse technology with progress.

Mark H. Miller, M.D.
Seattle, WA


Dr. T. Bedirhan Ustun, World Health Organization, July 9, 1999

Dear Dr. Varmus,

I am in the Editorial Board of the World Health Organization's Bulletin and work in the Organization. Your proposal on e-Biomed is the most sensible and revolutionary way to proceed forward. I have taken liberty to suggest that WHO should also support this proposal and promote its international use. I would be most delighted to discuss how best this could be achieved.

With best regards,
Dr. T. Bedirhan Ustun
Group Leader
Assessment, Classification and Epidemiology (ACE)
World Health Organization
Geneva Switzerland


Mark Bretscher, MRC Laboratory of Molecular Biology, Cambridge, England, July 9, 1999

Dear Dr Varmus,

There is an air of self-congratulation by many respondents about the excellent way in which the current journals serve the community. I disagree.

Journal editors used to act as arbiters about the appropriateness or otherwise of a manuscript and in so doing they sought the advice of specialists (referees) on technical matters. They then weighed up the advice and their own views in order to reach a balanced decision. However, many (if not most) editors now send the papers out to referees, tot up the + and - opinions and decide on that basis, with little or no thought of their own. The advent of "postmen" editors has led some referees to make unreasonable demands of authors, demands which should have been censored by a conscientious editor. And authors can have no dialogue with the editor about unfavourable decisions; the editor simply hides behind anonymous referees. All this introduces an unhealthy conservative element into science, particularly when authors feel constrained to write what they think they can get past the referees, as opposed to what they actually think. After all, the eventual paper is that of the authors, not of the referees, and they should be allowed to present their own views.

A lightly controlled alternative route to publishing, as conceived in mechanism 2, would by-pass this current evil and might force existing journals to reform their behaviours. This would benefit science in the long run.

Yours sincerely,
Mark Bretscher,
MRC Laboratory of Molecular Biology, Cambridge, England


July 8, 1999

Cyrus Wilson & Mark Gerstein, Yale University, July 8, 1999

This is a second comment on the E-Biomed Proposal sent to execsec1@od.nih.gov in response to solicitation at http://www.nih.gov/welcome/director/ebiomed/ebiomed.htm.

NIH's proposal for the e-biomed system highlights the changing nature of publishing as it moves online. The web is increasingly blurring the distinction between journals and databases. The search engine method of access and the repository structure of E-biomed and the Los Alamos e-print archives are reminiscent of large central databases, such as the GenBank gene-sequence collection. In this context, there is little difference between retrieving an online journal article and getting a free-text database report? Actually, as these web collections are not constrained by print or distribution schedules, they are not periodicals at all, in the literal sense, and are more accurately characterized as databases of articles.

Perhaps in the future the only distinction left between journal and database will be the intended audience. Journal articles will continue to be composed more for human reading, and database records, for machine parsing.

We have placed further comments on e-biomed and electronic publishing in a preprint at http://bioinfo.mbb.yale.edu/e-print/epub-ed-bioinfo.

Cyrus Wilson (college student, New Haven)
Mark Gerstein (assistant professor)


July 7, 1999

Dongsoo Kim, July 7, 1999

E-biomed is exactly what I have been longing for in the age of information superhighway and globalization. I give strong support for E-biomed!


July 6, 1999

Stevan Harnad, University of Southampton, July 6, 1999

On Tue, 6 Jul 1999, Fytton Rowland wrote:

> Professor Stevan Harnad argued quite a while ago that the models that he
> has advocated refer to "esoteric" publications (his term), which roughly
> fit the old assumption that the authorship and readership of a specialised
> scholarly journal are the same people. He has always recognised, I think,
> that other types of publication are different, and will continue to operate
> on a trade model paid for by a combination of income from advertisers and
> from purchasers. Such publications often (but not invariably) pay their
> contributors too. New Scientist would fit this description.

Under advice from Ann Okerson and others, the "esoteric" descriptor has now been dropped in favor of the (tautological) descriptor "nontrade," but in its place there is now a simple algorithm:

Does the author (1) seek/get any revenue for his text (royalties, fees) or does he instead (2) give it away, seeking only the eyes/minds of readers?

If (1), it is trade, if (2) it is not.

> However, Don King -- always an invaluable source of real, verifiable
> *facts* about scholarly journals as opposed to opinions and attitudes --

Thanks for the implied compliment (read on)...

> points out that many scholarly journals have a far wider readership than
> is necessarily indicated by their citation patterns.

Citation patterns are irrelevant to the trade/nontrade distinction. So is the size of the readership, according to the new, more precise algorithm above.

> It isn't true to say
> that only the authors ever read the journals -- the reader community is
> often wider.

It was never true to say that only the authors read even the most esoteric of journals. The authors (opting for (2)) always hoped to capture more eyes/minds than that, and occasionally even managed to do so.

But it was not just the rarefied subject matter of their articles that had conspired against these nontrade authors, who were seeking only eyes/minds for their texts; it was also the access barriers of (a) paper and (b) its economics, which necessitated toll-gates -- usually in the form of institutional Subscription/Site-License/Pay-Per-View (S/L/P) -- which denied entry for all unpaid eyes/minds to the author's freely given ideas/findings.

In the online era, both of these barriers to the eyes/minds of nontrade authors' potential readership have ceased to be necessary; this give-away literature can at last be freed for everyone, everywhere, forever:

http://www.arl.org/scomm/subversive/toc.html

> Examples would be: practitioners (physicians, engineers,
> lawyers, etc.) who don't actually do research; high school teachers; some
> of the educated lay public; and of course students, undergraduate as well
> as postgraduate.

Completely irrelevant: Tell a nontrade author trying to maximize the eyes/minds that access his work that he should NOT self-archive it publicly for free for all, because in some magazines some people are willing/able to pay for it!

> So far as really esoteric journals are concerned I think Professor Harnad
> is right; they do not belong in the commercial world at all, and an
> "author-pays" system, with a moderate charge to cover the costs of peer
> review and of maintaining the document on the WWW in perpetuity, seems
> appropriate.

The only open question -- and, thanks to the algorithm mentioned above, this is a matter of FACT, not opinion or attitude -- is: "Which are the 'really esoteric journals' that fall into this category?". The answer will be loud and clear: The ENTIRE REFEREED JOURNAL LITERATURE, which the author gives away to his publisher for free, seeking only the eyes/minds of readers in return.

> At the other end of the scale, Nature, for example, is a very successful
> commercial enterprise, and there is no way it will cease to be
> "reader-pays" - but in any case, high circulations attract advertising
> revenue and generally help to keep cover prices down.

Nature is hybrid. It has articles written by journalists for a fee, it has some borderline cases in which scientists are paid a very modest fee to provide commissioned articles, and it has the submitted, refereed reports of new research. The solution is simple: The trade portions can proceed apace, and the journal itself can continue to be sold via S/L/P for as long as there is a market. But the REFEREED articles can also be self-archived by authors for free for all.

Nature's copyright agreement regarding online self-archiving, unlike that of Science, is closer to the right direction on this, but eventually it will have to conform fully to the model provided by the American Physical Society, with full online self-archiving rights guaranteed for both the unrefereed preprint and the refereed reprint:

http://www.cogsci.soton.ac.uk/~harnad/Hypermail/Author.Eprint.Archives/0006.html

> There is a grey area in between, where journals such as those of the
> American Chemical Society, for example, have a large sale to commercial
> chemical and pharmaceutical companies. There is no reason on earth why
> academia should subsidise *them*, so surely a "reader-pays" system should
> stay. The argument comes down to this: how do we draw the lines between
> the different types of scholarly journal? -- Fytton Rowland

Completely incorrect! The fact that institution X is willing and able to pay for an ACS journal via S/L/P is of absolutely no use to ME if I am in institution Y or country Z, which isn't. Nor is it of any use to the author of that article that my eyes/mind and countless others continue to be denied access to his work because there are still others who can afford not to be!

http://www.cogsci.soton.ac.uk/~harnad/nature.html

--------------------------------------------------------------------
Stevan Harnad
Professor of Cognitive Science
Computer Science
University of Southampton
UNITED KINGDOM
http://www.cogsci.soton.ac.uk/~harnad/
http://www.princeton.edu/~harnad/
ftp://ftp.princeton.edu/pub/harnad/


Ted Reid, July 6, 1999

I think this is a great idea. As a person who spends many hours a month doing reviews for scientific journals for no compensation, I think it is time for scientists to regain control of their own work. All any scientist wants is for his or her work to be read by the maximum number of other scientists and interested parties. At the moment many libraries can not afford to subscribe to many of the current journals and thus many important pieces of information are difficult to access. A system that provides for peer review and still allows for an open exchange of ideas without the current obstructions is a great step forward.


Norma Neff, Ph.D., Laboratory of Human Genetics, New York Blood Center, July 6, 1999

The currency of the digital age is information. Lack of access to journals because of economic scarities at small institutions and in other countries allows a monopoly of information in a small number of the wealthiest institutions. There is no lack of ideas at less affluent institutes, just the means to test models. New information circulates rapidly in the small circles of academic focus groups but reaches the general scientific community more slowly. The groups to benefit the most are the small research institutions, biotech industry and other countries. More rapid information to biotechs could potentially bring new products to market. As the biotech industry is likely to benefit - why not make this a partnership between the federal government and the drug industry? This is an opportunity to payback the federal government for creating and expanding the knowledge base that made the industry.

Smaller more specialized journals would benefit from the international exposure. Potentially this proposal would lead to more journals and more open participation in peer review such that a few individuals could no longer control areas of research.

This proposal would create some new lifestyle changes for the average lab worker. This would eliminate the free lab rat health club - such as having to go to another building to find an article. The elimination of the hour needed to go to another building or institution, go up and downstairs to find the journal, haul the ten pound journal up and downstairs to find a copy machine that works to make a poor copy. Contrast this with five minutes to send a copy to everyone in the lab.

Norma Neff, Ph.D.
Laboratory of Human Genetics
New York Blood Center
New York, NY


July 5, 1999

Stevan Harnad, University of Southampton, July 5, 1999

On Fri, 2 Jul 1999, Frank Norman wrote:

> I have been following your perceptive and (to me) convincing
> arguments about the merits and demerits of the e-biomed proposal
> from Harold Varmus et al.
>
> In your posting on June 27th you said:
>
> > Quality control will continue to be an essential service, however, and its
> > costs will be recoverable from S/L/P savings by abandoning the
> > reader-institution-end trade model for an author-institution-end
> > publication-charge model that is far more suited to this very anomalous
> > and special form of literature: the refereed research corpus.
>
> If this comes to pass, I can envisage that the more highly
> prestigious titles (Science, Nature, Cell etc) will demand higher
> publication charges than journals lower down the hierarchy. Indeed,
> it may be that there is a very substantial premium to be accepted
> by the most prestigious titles. One effect of this could be to
> prevent less well-financed research groups from publishing in high-
> prestige journals. They'll be able to access the content of such
> journals for free but will not be able to afford to publish in them.
>
> Is this how you see things working out? How could this outcome
> be circumvented?
>
> Frank Norman
> Acting Librarian
> National Institute for Medical Research
> The Ridgeway, Mill Hill
> London, UK
>
http://www.nimr.mrc.ac.uk/personal/Frank

Nothing like this will happen; it is based on a misunderstanding of peer review -- and of what it is that makes the prestigious journals prestigious, and hence makes authors prefer to submit papers to them rather than elsewhere:

The prestige of the top journals is based on their quality, which in turn depends on their quality-control standards: They only accept the very best papers (and their typically high rejection rates and citation impact factors reflect this). (They are not "designer labels," for the patina of which a "consumer" is willing to pay more!)

The way high standards of quality are maintained is through rigorous peer review: One cannot BUY success in that process; authors must EARN it (by doing high quality work). Otherwise the prestigious journals would simply lose their prestige (and be replaced by other, more rigorously refereed journals, that recaptured their standards, and THEREBY the best papers [no, they will not LOWER their charges to capture to higher-prestige authors either! this sort of market-thinking is all based on the wrong, old, reader/consumer-end model: or, to put it another way, the "competition" in this highly anomalous, nontrade, research literature is for high-quality papers, not for author-dollars.]).

On the contrary, it is much lower down in the peer review hierarchy, as one approaches the vanity press, that some abuse of the author-end system is conceivable: Authors may try to buy their way into the pages of low-quality journals when they have failed to earn their way into the high-quality ones. But, frankly, I don't find this at all worrisome! Vanity publications are apparent to everyone; they wear the result (low quality) on their sleeves (and their contents, their authorships, their rejection rates and their impact factors); and such journals already exist today, where the "subsidy" currently comes on the reader-institution-end rather than the author-institution-end -- everyone knows which ones they are, and that "caveat emptor" prevails when it comes to deciding whether to read them or rely on what they report.

http://helix.nature.com/webmatters/invisible/invisible.html

The costs of submitting to the high-quality journals will be close to the true costs of implementing peer review, for that is all it will involve (and the peers do not request or receive remuneration; they referee according to the Golden Rule: it is only the IMPLEMENTATION of the refereeing that incurs some cost); it is the vanity press that may have to bribe referees (at the author's cost).

(Unaffiliated authors, with no institution to fund them out of annual windfall S/L/P-cancelation savings and no funding agency to cover the minuscule publication costs can be funded from collective publication slush funds established for this purpose at the journal or suprajournal level. So this too should not detain us.)

Let me close with two further points:

(1) It is inadvisable to try to second-guess outcomes in this way; it is all too hypothetical, and for everything we think of in advance, there will no doubt be several unexpected contingencies we didn't think of. This isolated single-variable second-guessing simply helps entrench the status quo, because so many people have vested interests in retaining it -- or merely prefer to do and change nothing.

So forget about author-end page charges! They will sort themselves out. The ONLY salient thing at this moment is the absolutely unambiguous desideratum that all authors should self-archive their refereed papers NOW and ensure that no copyright agreement ventures to block that capability. That will effectively free the journal literature. The rest will take care of itself.

(2) There is another Harnad, not myself, but a mathematical physicist by the name of John Harnad (and the one who first drew my attention to the Ginsparg Archive way back in the early '90's). J. Harnad has some further recommendations on the subject of referee answerability and compensation: He recommends that (a) all referees should be paid to referee papers; (b) payment for a rejected paper should be minimal (say, $200), but payment for an accepted paper should be commensurate with the effort of seeing it through the successive revisions (say, $2000) to successful publication; and, to avoid the potential abuse discussed above, (c) if a paper is accepted, the name of the accepting referee(s) should be co-published with it, to share the responsibility, praise or blame. He feels this would raise the quality of the refereeing and make the entire process much more answerable, hence effective, than it is now.

Obviously this proposal is compatible with the transition from reader-institution-end payment to author-institution-end payment, but it is an as yet untested peer-review reform proposal; all such reform proposals need to be tested empirically and practically before being implemented on any scale. Hence it should not detain us on the road to freeing the CURRENT refereed literature, such as it is.

(I also think that there is not enough money in the world to pay fairly for the precious time that referees steal from their own research in order to do the mostly thankless task of peer review; hence the Golden Rule is probably the only one we can continue to rely on! SUBMISSION charges, creditable toward PUBLICATION charges should the paper be accepted, may not be a bad idea to levy on authors, though, with or without referee payment, for it to might help raise submission standards and even revision conscientiousness, hence perhaps even lightening some of the burden on the work-horse referees; but this too would need pre-testing.)

Stevan Harnad
Professor of Cognitive Science
Department of Electronics and Computer Science
University of Southampton
UNITED KINGDOM http://www.cogsci.soton.ac.uk/~harnad/
http://www.princeton.edu/~harnad/
ftp://ftp.princeton.edu/pub/harnad/


Mostafa K. Mohamed, AinShams University, Cairo, Egypt, July 5, 1999

I should start with my full support of your efforts and proposed international scientific electronic publishing project. I would only like to see that you have also an international editorial board for each particular speciality that you will include in this overwhelming scientific base (biomedical may cover hundreds of specialities as you propably recognize from the responses to your proposal). I will be happy to be of any assistance for further development of your efforts. The electronic exchange of ideas and information has revolutionized the scientific communication and people thousands of miles away can work simultaneously, somoothly, with little cost to acheive a particular task like this.

Sincerely yours
Mostafa K. Mohamed
Professor of Community, Environmental and Occupational Medicine
Faculty of Medicine
AinShams University
Cairo, Egypt


David R. Rigney, Ph.D., GENETWORKS Inc., Austin, Texas, July 5, 1999

As noted by others in their comments on E-Biomed, the plan to provide full access to the entire biomedical research literature will greatly facilitate meta-analyses, especially if authors are encouraged to submit their original data along with their manuscripts. E-Biomed will also greatly facilitate the interpretation of functional genomic data, such as those acquired using gene expression microarrays. It is difficult to comprehend the relation between expression levels of thousands of genes, without considering the entire collection of publications that link each gene to all the others. As a practical matter, this may only be possible by using E-Biomed in conjunction with advanced software tools for searching within full text publications, analysis involving linked genomic databases, and computer modeling of complex, integrated systems. (Related issues are discussed by Dr. Varmus at (http://www.nih.gov/welcome/director/021398.htm)

David R. Rigney, Ph.D.
GENETWORKS Inc., Vice President for Research and Development
Austin, Texas


Prof. Peter Csermely, International Research Scholar of the Howard Hughes Medical Institute, July 5, 1999

Dear Sirs,

as an organizer and representative of the recently concluded International Forum of Young Scientists (a satellite of the World Conference on Science) I fullheartedly support your e-Biomed initiative.

Let me emphasize two aspects of the new project which may ensure that even the communcations, which have not undergone a peer-review system will contain interesting and valid data:

-- the possibility to attach comments (I would like to add: comments from identifyable IP addresses, with name and email-address)
-- the possibility of authors to add responses as well as to change the text of the manuscript later (in a recorded manner)
-- and as a new requirement: the staff should ensure that all corresponding authors make a note of any email address changes. Email addresses of corresponding authors should be regularly checked in a random manner and those found nonresponding should be clearly marked as materials where the author can not be directly reached for comments or other verifications.

It is very delightful and assuring to see that you took all the burden to establish this new forum which answers to so many of the problems I raised in my recent Science letter (vol. 284, pp. 1622-23). My own lab has several important contributions, which would only fit to the "second" (non-peer-reviewed) part of e-Biomed.

Best personal regards,
Prof. Peter Csermely
International Research Scholar
of the Howard Hughes Medical Institute