Overview

Through the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, NIH supports research to enhance pain management and improve treatment for opioid misuse and addiction. The NIH HEAL Initiative includes research focus areas led by most NIH Institutes and Centers supporting hundreds of projects that reflect the full spectrum of research from basic science to implementation research.

HEAL Policy for the Enrollment of Participants in Clinical Trials

Clinical trials to identify and test new safe and effective treatment approaches for opioid use disorder and chronic pain are an essential component of HEAL research. To ensure that such clinical trials are conducted as safely and efficiently as possible, researchers must meet certain requirements when recruiting study participants. These requirements are specified in the HEAL Policy for the Enrollment of Participants in Clinical Trials, which also outlines the responsibilities of Principal Investigators and relevant NIH staff.

Read CT Enrollment Policy

Funded Projects

2023
The Impact of Community Infrastructure Reinvestment Programs on Opioid Misuse and Opioid Overdose
Nov 28, 2023
2023
Value of Sleep Metrics in Predicting Opioid Use Disorder Treatment Outcomes: Leadership and Data Coordinating Center
Nov 28, 2023
2023
Implementing a Patient Navigation Intervention Across a Health System to Address Treatment Entry Inequities
Nov 28, 2023
2023
ADAPT: Adaptive Decision Support for Addiction Treatment
Nov 28, 2023
2023
Development and Validation of a Novel Point-of-Care Technology for Rapid Non-Targeted Identification of Emerging Opioid and Other Drug Threats
Nov 28, 2023

Open Funding Opportunities

2023
HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)
Aug 11, 2023
2023
HEAL Initiative: Toward Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required)
Jun 09, 2023
2023
HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)
Apr 27, 2023
2023
HEAL Initiative: EPPIC-Net Pain Research Asset Application – Dossier (OT2)
Apr 20, 2023
2023
Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)
Apr 20, 2023

Closed Funding Opportunities

2022
HEAL Initiative: EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
Jun 03, 2022
2022
HEAL Initiative: EPPIC-Net Pain Research Asset Application – Dossier (OT1) [ROLLING SUBMISSION ACCEPTED: BY INVITATION ONLY]
Jun 03, 2022
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL) (R01 Clinical Trial Required)
Jul 11, 2022
2022
HEAL Initiative: Multilevel Interventions to Reduce Harm and Improve Quality of Life for Patients on Long Term Opioid Therapy (MIRHIQL): Resource Center (U24- Clinical Trial Optional)
Jul 11, 2022
2020
HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)
Jan 23, 2020