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Funded Projects

RADx Underserved Populations (RADx-UP)

Project Title: Predicting Diabetic Retinopathy from Risk Factor Data and Digital Retinal Images
Awardee: Charles R. Drew University of Medicine and Science
Project Number: 3R01LM012309-04S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will use a multidisciplinary, mixed-methods approach including unsupervised machine learning (ML) and qualitative interviews to systematically explore barriers and facilitators to COVID-19 testing among vulnerable populations. 

Project Title: Reaching Communities through the Design of Information Visualizations (ReDIVis) Toolbox for Return of COVID-19 Results
Awardee: Columbia University Health Sciences
Project Number: 3P30NR016587-05S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will address health disparities by creating culturally congruent infographics to support comprehension of testing results, increase understanding, and approach next steps for patients in East Harlem, NY.

Project Title: Increasing Representation of Black Communities in SARS-Cov-2 Serosurveys by Understanding Barriers and Motivations for Participation
Awardee: Georgia State University
Project Number: 3R01DA051302-01S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will identify barriers and motivations to COVID-19 testing and vaccination among black populations, particularly as it relates to participation in existing serosurveys. 

Project Title: Howard University Research Center for Minority Health and Health Disparities
Awardee: Howard University
Project Number: 3U54MD007597-32S2
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will develop strategies and best practices for COVID-19 interventions for Blacks/African Americans in the Washington D.C. metropolitan area. 

Project Title: Exploring Barriers and Facilitators to Women Who Use Drugs (WWUD) Awareness, Acceptance and Uptake of COVID-19 Testing, the CARE study
Awardee: Johns Hopkins University
Project Number: 3R01DA041243-05S2
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will examine the behaviors, social, and structural factors correlated with testing and repeat testing among a cohort of women with substance abuse disorders in the Baltimore area.

Project Title: Continuous Traumatic Violence and the HIV Continuum of Care Outcomes Among BMSM
Awardee: Medical College of Wisconsin
Project Number: 3R21MH122010-01S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will characterize the convergence of three public health crises: the convergence of COVID-19, systemic racism, and community and police violence to understand how these may affect COVID-19 testing decisions among African Americans in the Chicago area. 

Project Title: Bridging the Evidence-to-Practice Gap: Evaluating Practice Facilitation as a Strategy to Accelerate Translation of a Systems-Level Adherence Intervention into Safety Net Practices
Awardee: New York University School of Medicine
Project Number: 3R01MD013769-02S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will gain a comprehensive understanding of the multilevel factors that drive uptake of testing (and future vaccination) for COVID-19 and participation in follow-up care offered by safety-net health systems in Black and Latino/a patients.

Project Title: Getting Asian Americans INFORMED to Facilitate COVID-19 Testing and Vaccination
Awardee: University of California, San Francisco
Project Number: 3R01DA036749-05S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will evaluate a novel approach “Individual and Family-Oriented Responsive Messaging and Education” (INFORMED) that combines lay health worker education outreach with automated text messaging to facilitate COVID-19 testing uptake in Chinese, Hmong and Vietnamese Americans in urban and rural communities. 

Project Title: Social, Ethical, and Behavioral Implications (SEBI) Research on COVID-19 Testing and Vaccine Uptake among Rural Latino Migrants in Southwest Florida
Awardee: University of South Florida
Project Number: 3R34AT010661-01S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will utilize the Hispanic Services Council (HSC) and promotoras de salud to develop population specific marketing strategies and community education regarding COVID-19 testing and vaccination to increase COVID-19 testing across a diverse set of communities.

Project Title: Expanding Population-Level Interventions to Help More Low-Income Smokers Quit
Awardee: Washington University
Project Number: 3R01CA235773-02S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will identify essential constructs for communication of testing to vulnerable populations through the 211-call center, integrating new knowledge into proven messaging tactics, and evaluating these new strategies and interventions. 

Project Title: Assessing Vaccine Hesitancy and a Pharmacist Led Intervention Model to Increase COVID-19 Vaccine Uptake Among African Americans
Awardee: Xavier University of Louisiana 
Project Number: 3U54MD007595-12S4
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will assess vaccine hesitancy and conduct a pharmacist-led intervention to increase COVID-19 vaccine uptake among African Americans.

Project Title: Leveraging Social Networks to Increase COVID-19 Testing Uptake: A Comparison of Credible Messenger and Chain Referral Recruitment Approaches
Awardee: New York State Psychiatric Institute
Project Number: 3UG1DA050071-02S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will focus on individuals that use opioids and other substances to improve testing within this New York City community.

Project Title: HIV/AIDS Clinical Trials Unit (CTU) COVID-19 RadX-UP Supplement
Awardee: University of North Carolina at Chapel Hill
Project Number: 3UM1AI069423-15S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will focus on rapidly improving testing in underserved Black and Hispanic/Latino communities in rural central North Carolina. 

Project Title: Obesity Health Disparities Research Center (OHDRC) - COVID-19 Testing Model among Vulnerable Populations: From Community Engagement to Follow-Up
Awardee: University of Alabama at Birmingham
Project Number:  3U54MD000502-18S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will implement a mobile, community-based testing model and evaluate its impact to improve testing and increase overall acceptance uptake.

Project Title: COVID-19 testing in Underserved and Vulnerable Populations Receiving Care in San Diego Community Health Centers
Awardee: University of California, San Diego
Project Number: 3UH3CA233314-02S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will develop, test, and evaluate a rapid and scalable capacity project to increase COVID-19 testing in San Diego, CA. The study will focus on at-risk, socioeconomically disadvantaged individuals, particularly vulnerable populations with comorbidities who are age 65 or older. 

Project Title: Determinants and Outcomes of Nicotine Metabolite Ratio in HIV + Smokers
Awardee: University of Pennsylvania
Project Number: 3R01HL151292-01S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will examine an intervention that draws parallels between COVID-19 and HIV/AIDS among Black and Hispanic/Latino populations in Philadelphia, PA.  The approach will include secondary COVID-19 self-test distribution to individuals and their social networks. 

Project Title: COVID-19 Testing and Linkage to Care with African American Church and Health Agency Partners
Awardee: University of Missouri, Kansas City
Project Number: 3R01DK124664-01S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will examine a church-based intervention to increase rates of COVID-19 testing in a primarily African American community in Kansas City, MO. 

Project Title: Optimization of a new adaptive intervention to increase COVID-19 testing among people at high risk in an urban community
Awardee: University of Illinois at Urbana-Champaign
Project Number: 3R01MD010629-04S2
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will define the process by which medical or socially vulnerable people seek out COVID-19 tests and results. 

Project Title: Safety, Testing/Transmission, and Outcomes in Pregnancy with COVID-19 (STOP-COVID-19 study)
Awardee: Washington University
Project Number: 3R01HD091218-04S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: In this study, researchers will perform antibody testing to determine how asymptomatic COVID-19 infection in pregnancy increases risk of adverse pregnancy outcomes.

Project Title: Epidemiologic Intelligence Network (EpI-Net) to Promote COVID-19 Testing and Prevention Practices Among Socially Vulnerable Communities in Puerto Rico
Awardee: Ponce School of Medicine
Project Number: 3R21MD013674-02S2
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will evaluate the impact of an epidemic intelligence (EpI-Net) community-based intervention aimed at increasing COVID-19 testing uptake and prevention practices among socially vulnerable populations in Puerto Rico. 

Project Title: Prevention of Substance Use in At-risk Students: A Family-centered Web Program
Awardee: University of Oregon
Project Number: 3R01DA037628-05S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will use community-based participatory approaches to develop, implement, and evaluate a COVID-19 testing program offered through syringe services programs, a natural point of care for persons who inject drugs. 

Project Title: Connecting our Neighborhoods Need for Enhanced and Coordinated Testing to Achieve Equity: CoNNECT to Achieve Equality
Awardee: University of Arkansas for Medical Sciences
Project Number: 3R01MD013852-02S3
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will focus on increasing COVID-19 testing among Latino/a and Native Hawaiian/Pacific Islander communities in two counties in Northwest Arkansas. 

Project Title: Center for American Indian and Rural Health Equity
Awardee: Montana State University, Bozeman
Project Number: 3P20GM104417-07S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will use pragmatic randomized testing to evaluate home based testing through comparing community health workers with mail in at-home testing and their related feasibilities. 

Project Title: Alive Church Network: Increasing COVID-19 Testing in Chicago’s African American Testing Deserts
Awardee: Rush University Medical Center
Project Number: 3R01NR018463-01S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will leverage an existing coalition of African American pastors and academics in Chicago to conduct an evaluation for COVID-19 testing in areas with limited testing.

Project Title: Investigating the Effectiveness of COVID-19 Testing Choices, Community Engagement, and Culturally-Embedded mHealth Literacy Delivery in a Medically-Underserved, Community-Based Sample
Awardee: University of Illinois at Chicago
Project Number: 3R01ES028615-06S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will provide central community-based surveillance approaches via smartphone apps for African Americans and Hispanic communities in the broader Chicago area.

Project Title: Louisiana Clinical and Translational Science Center
Awardee: Louisiana State University Pennington Biomedical Research Center
Project Number: 3U54GM104940-05S3
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will determine testing rates for multiple testing sites and community-driven approaches for increasing uptake in underserved Black urban communities in Louisiana. 

Project Title: Keeping Rural Minority Essential Workplaces Open Safely During The COVID-19 Pandemic: The Role of Frequent Point-of-Care Molecular Workplace Surveillance for Miners
Awardee: University of New Mexico Health Sciences Center
Project Number: 3U01GM132175-02S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will focus on workplace surveillance and monitoring to increase the acceptance rate of testing and prevent COVID-19 infections among miners in the Southwest.

Project Title: Implementing Community-based Approaches to Increase SARS-CoV-2 Testing among an Underserved and Vulnerable Hispanic Population
Awardee: University of Texas at El Paso
Project Number: 3U54MD007592-27S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will integrate academic, non-profit, business, and public partners in El Paso, TX, to reduce SARS-CoV-2 testing deficiencies through providing testing information, navigation strategies, and implementing local pop-up testing sites. Researchers will implement strategies that target the cultural, social, and behavioral factors characteristic of this population. 

Project Title: Puipuia le Ola: Increasing Reach and Uptake of COVID-19 Testing Among Pacific Islanders in Hawaii and Guam
Awardee: University of Hawaii at Manoa
Project Number: 3P30GM114737-05S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will develop and evaluate culturally tailored community interventions for outreach COVID-19 testing among Pacific Islanders in Hawaii and Guam.

Project Title: Building Resilience and Vital Equity (BRAVE) - Increasing COVID-19 Testing in American Indians
Awardee: North Carolina Central University
Project Number: 3R01MD012767-04S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This study will evaluate the impact of work to increase testing uptake for American Indians in North Carolina. 

Project Title: Prevention Research Center: Parenting Among Women Who Are Opioid Users
Awardee: University of Oregon
Project Number: 3P50DA048756-02S2
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This project addresses a community-tailored outreach program for the Latina population within six counties in Oregon. It will examine the rural-urban distinction, with a sensitivity to geographical approach that will be imperative for later scaling efforts.

Project Title: Clinical and Translational Science Award
Awardee: Medical College of Wisconsin
Project Number: 3UL1TR001436-06S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This project will perform community-engaged research using randomized COVID-19 tests among vulnerable populations in Milwaukee County, Wisconsin. The study will focus on understanding COVID infection and progression rates and how they vary with patient characteristics.

Project Title: Protecting Native Families from COVID-19: RADx Initiative
Awardee: Johns Hopkins University
Project Number: 3U19MH113136-04S2
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will address high rates of morbidity and mortality due to COVID19 among American Indian (AI) and Navajo Nation (NN) communities in the US. The goal of this study is to increase and speed up the testing among those with symptoms and improve adherence to recommended strategies.

Project Title: Improved Testing for COVID-19 in Skilled Nursing Facilities: IMPACT-C
Awardee: Brown University
Project Number: 3U54AG063546-02S2
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This project will leverage an existing National Institute of Aging Imbedded Pragmatic Alzheimer’s Disease/Alzheimer’s Disease Related Dementias Clinical Trials (IMPACT) Collaboratory to establish IMPACT-COVID-19, a collaborative that aims to develop and evaluate SARS-CoV-2 testing strategies in highly-vulnerable, skilled nursing facilities’ (SNF) residents and workers.

Project Title: Community Network Driven COVID-19 Testing of Vulnerable Populations in the Central US
Awardee: University of Chicago
Project Number: 3UG1DA050066-02S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This project will evaluate the impact of an evidence-based Social Network Testing Strategy (SNS) combined with community developed COVID-19 public health messages (SNS+).

Project Title: COVID-19 Testing and Prevention in Correctional Settings
Awardee: Yale University
Project Number: 3UG1DA050072-02S3
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will work with diverse correctional facilities across MN, RI, WA, and FL to characterize the incidence of COVID-19 disease progression and related outcomes. The goal is to identify barriers and facilitators to develop strategies to improve testing in these underserved populations.

Project Title: The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health
Awardee: Ohio State University
Project Number: 3UL1TR002733-03S3
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will address and reduce the disparities in COVID-19 education, testing, contact testing, follow-up and treatment among minority, underserved, vulnerable populations in 12 selected counties in Ohio.

Project Title: Community-Engaged Research on COVID-19 Testing in the US Territories
Awardee: Yale University
Project Number: 3U54MD010711-05S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will enhance COVID-19 testing and implementation using community-engaged research in the Caribbean Islands, Puerto Rico (PR) and the U.S. Virgin Islands (USVI), both with high proportions of high-risk populations, including Black and Latino/Latina populations.

Project Title: RADx-UP NARCH Supplement: A Cherokee Nation Community-Driven Program for Testing and Contact Tracing (Cherokee PROTECT)
Awardee: Cherokee Nation
Project Number: 3S06GM127983-03S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will enhance understanding of COVID-19 within the significantly and disproportionally impacted residents of Cherokee Nation. The researchers will perform rapid point-of-care testing, antibody testing, and contact tracing, and will develop educational materials for the community. Rapid data analysis will be used to nimbly move testing sites to areas of need.

Project Title: Community Driven Approach to Mitigate COVID 19 Disparities in Hawaii's Vulnerable Populations
Awardee: University of Hawaii at Manoa
Project Number: 3U54MD007601-34S2
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will close testing gaps and eliminate COVID-19 disparities among Native Hawaiian and other Pacific Islanders (NHPI) and Filipinos living in rural and underserved communities in Hawaii by integrating innovative SARS-CoV-2 testing capacity with novel community-specific messaging and education.

Project Title: Leveraging Bio-Cultural Mechanisms to Maximize the Impact of Multi-Level Preventable Disease Interventions with Southwest Populations
Awardee: Arizona State University-Tempe Campus
Project Number: 3U54MD002316-14S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will perform targeted SARS-CoV-2 testing within defined testing deserts in Arizona and will compare a subset of affected individuals who undergo the proposed testing and educational protocol with those who receive the same testing through standard systems available in the state.

Project Title: Monitoring COVID-19 and Building Capacity with Northern Plains Tribes and the Future of Pandemics
Awardee: Stanford University
Project Number: 3U54MD010724-05S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will upgrade and sustain local capacity at the Native BioData Consortium (NBDC) with training and development of Personal Protective Equipment (PPE) and Lab Protocols to improve COVID-19 testing and outcomes for Tribal populations by creating an improved diagnostics lab/local data resource and by testing the use of wearables on early diseases detection.

Project Title: ORALE COVID-19: Organizaciones para Reducir, Avanzar y Lograr Equidad contra el COVID-19 (Organizations to Reduce, and to Advance, and Lead for Equity against COVID-19)
Awardee: University of California, Davis
Project Number: 3P30ES023513-06S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will understand and overcome the barriers to testing for SARS-CoV2 in Latino/Latina populations in California's central valley through interventions to increase testing.

Project Title: Community-Academic Partnership to Address COVID-19 Among Utah Community Health Centers
Awardee: University of Utah
Project Number: 3UL1TR002538-03S4
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will employ 39 community health centers across the state to help underrepresented individuals using three pathological, multilevel interventions to increase screening and testing uptake. This technology-based strategy will employ the use of EHR record analysis and text screening to identify high-risk individuals and connect them to patient navigators.

Project Title: Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations
Awardee: Florida International University
Project Number: 3U01DA040381-05S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will improve testing uptake in Miami Dade county through a community-based approach that includes a community advisory board and community surveys to determine the best approach to testing and receptiveness of different sample collection approaches.

Project Title: The Johns Hopkins Center for AIDS Research (JHU CFAR) RADx-UP
Awardee: Johns Hopkins University
Project Number: 3P30AI094189-09S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will perform a cluster-randomized trial comparing the effectiveness of three testing strategies to address COVID-19 testing disparities among African American, Latino/Latina, and socioeconomically disadvantaged populations in Baltimore.

Project Title: Implementation Science Center in Cancer Control Equity: A Competitive Revision to Accelerate COVID Testing in Vulnerable Communities
Awardee: Harvard School of Public Health
Project Number: 3P50CA244433-02S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will accelerate COVID-19 testing in nine Massachusetts communities and six community health centers through a community-engaged approach. The study will create and implement an infrastructure to improve testing and evaluate its impact and further integrate with community partners, outreach training to residents, and provide clinical training to community health clinic personnel.

Project Title: Communities Fighting COVID!
Awardee: San Diego State University
Project Number: 3U54CA132384-10S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will use community health workers for outreach to underserved populations (Latino/Latina, African American, Filipino, and immigrant communities) in the San Diego area to facilitate COVID-19 testing.

Project Title: A Nurse-Community Health Worker-Family Partnership Model to Increase COVID-19 Testing in Urban Underserved and Vulnerable Communities
Awardee: New York University
Project Number: 3P30-DA-011041-23S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: The study will leverage the investigators’ longstanding community partners in Mott Haven in South Bronx, NY, and existing infrastructure to increase COVID-19 screening and access to results.

Project Title: A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)
Awardee: University of Alabama at Birmingham
Project Number: 3P30AI027767-32S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will evaluate the implementation of a rapid scale-up SARS-CoV-2 testing strategy (ADAPT framework including Assessment, Preparation, and Implementation Phases) in Alabama with goal of maximizing the outreach to underserved communities disproportionately impacted by COVID-19.

Project Title: Harnessing Technological Innovation and Community-Engaged Implementation Science to Optimize COVID-19 Testing for Women and Children in Underserved Communities
Awardee: University of California, San Diego
Project Number: 3P42ES010337-19S2
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study seeks to maximize COVID-19 testing amongst pregnant women and children in an area of the San Diego district near the United States-Mexico border that has been noted to have the highest incidence of COVID-19.

Project Title: WUIDDRC Supplement-Supporting the Health and Well-being of Children with Intellectual and Developmental Disability during COVID-19 Pandemic
Awardee: Washington University
Project Number: 3P50HD103525-01S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will determine the best implementation strategies to maximize the use of an FDA-approved diagnostic test for vulnerable children with intellectual and developmental disabilities (IDD) in a school setting at Washington University.

Project Title: New Jersey Alliance for Clinical and Translational Science: NJ ACTS
Awardee: Rutgers Biomedical and Health Sciences
Project Number: 3UL1TR003017-02S2
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study proposes COVID-19 screening programs serving lower-income health care workers and support staff. The study aims to catalyze COVID-19 testing in their households, extended families/networks, and ultimately, amplify community-based testing in vulnerable, underserved populations among low-income, Black and Latino/Latina minority communities in New Jersey counties.

Project Title: Rapid Optimization of COVID-19 Testing for People Affected by Diabetes
Awardee: Emory University
Project Number: 3P30DK111024-05S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will optimize testing for minority populations affected by diabetes and associated comorbidities including pre-diabetes and obesity. An iterative testing strategy will be implemented at federally qualified health centers that provide care for uninsured and at-risk individuals and community engagement techniques.

Project Title: Center for Clinical and Translational Sciences (CCTS)
Awardee: University of Texas Health Science Center at Houston
Project Number: 3UL1TR003167-02S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will identify dynamic disease hotspots and testing deserts in racially diverse regions of South (Houston/Harris County) and Northeast Texas.

Project Title: Developing Novel Strategies to Increase COVID-19 Testing among Underserved and Vulnerable Populations in West Virginia through Community and State Partnerships
Awardee: West Virginia University
Project Number: 3U54GM104942-05S3
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study proposes to address COVID-19 testing disparities by enhancing COVID-19 testing among rural primary care offices located across West Virginia, intensifying COVID-19 testing through mobile vans in areas forecasted to experience a near-term increase in COVID-19 incidence, and further increasing COVID-19 testing in Black/African American communities through dedicated mobile van and home testing.

Project Title: RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in COVID-19 Testing
Awardee: University of Kansas Medical Center
Project Number: 3UL1TR002366-04S3
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study proposes to examine the effectiveness of a Learning Collaborative's effort that helps local community organizations address disparities in COVID-19 testing by building “Local Health Equity Action Teams” in 10 disproportionally COVID-19-affected counties.

Project Title: Community Organizations for Natives: COVID-19 Epidemiology, Research, Testing, and Services (CONCERTS)
Awardee: Washington State University
Project Number: 3U54MD011240-05S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study focuses on satellite centers that partner with six geographically contiguous Urban Indian Health Programs (UIHPs) across the United States to launch studies under Community Organizations for Natives: COVID-19 Epidemiology, Research, Testing, and Services (CONCERTS). The overarching goal is to remove barriers and increase SARS-CoV-2 testing among urban American Indian/Alaska Native populations by offering an array of testing options that cover a wide geographical area.

Project Title: Oklahoma Shared Clinical and Translational Resources
Awardee: University of Oklahoma Health Science Center
Project Number: 3U54GM104938-08S1
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study will leverage existing community partnerships to help overcome the lack of robust public health infrastructure and healthcare in Oklahoma to address gaps in COVID-19 testing in rural populations.

Project Title: Collaborative Community Networks to Optimize Implementation of Low Barrier COVID-19 Testing Efforts among Diverse Latinx Populations in Northern California 
Awardee: University of California, San Francisco
Project Number: 3P30AI027763-29S1​
Funding Opportunity Announcement: NOT-OD-20-121
Summary: This study aims to implement and evaluate community-engaged approaches to improving access and uptake of COVID-19 testing in Latino/a communities in Northern California and understand local epidemiology and factors driving the stark ethnic disparities observed in COVID-19 case rates.

Project Title: Evaluation of Smoke-Free Housing Policy Impacts on Tobacco Smoke Exposure and Health Outcomes
Awardee: New York University School of Medicine
Project Number: 3R01CA220591-03S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This proposal aims to increase access and determine community-informed preferences for testing using a community health worker-facilitated comparative effectiveness study in the New York Housing Authority.

Project Title: Rhode Island Center for Clinical and Translational Science
Awardee: Brown University
Project Number: 3U54GM115677-05S1
Funding Opportunity Announcement: NOT-OD-20-120

Summary: This project is targeted to increase testing in the Rhode Island Latino/Latina community through partnerships with community clinics.

Project Title: Juntos (Together): A community led approach to enhance to COVID-19 testing among vulnerable Latinos
Awardee: Johns Hopkins University
Project Number: 3-R01DA045556-04
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This proposal looks to increase access and uptake of testing in the Latino/Latina community in Baltimore using a combination of social media strategies and community navigators to connect individuals to care. This testing campaign will center on a bilingual website that addresses community concerns and allows identification of testing sites.

Project Title: LITE CONNECT: Addressing testing gaps and epidemiologic disparities of COVID-19 among transgender people in the United States
Awardee: Johns Hopkins University
Project Number: 3UH3AI133669-04S1
Funding Opportunity Announcement: NOT-OD-20-120
Summary: This project aims to better understand barriers and facilitators of testing in the transgender community using an internet-based approach and a home testing strategy.

Project Title: Advancing Palliative Care in Northern Plains American Indians
Awardee: Massachusetts General Hospital
Project Number: 3R01CA240080-02S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This research will perform a phased study of three Lakota tribes in South Dakota to address attitudes and access to testing.

Project Title: Use of Behavioral Economics in Repeat SARS-CoV-2 Antibody Testing in Disadvantaged Communities
Awardee: University of Southern California
Project Number: 3R33AG057395-04S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study is looking to investigate the social and behavioral determinants of COVID-19 testing in the Hispanic population in Los Angeles.

Project Title: Role of Alcohol Disparities in HIV Risk among Sexual Minority Youth
Awardee: Northwestern University at Chicago
Project Number: 3R01AA024409-05S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will analyze COVID-19 testing among marginalized and understudied racial/ethnic minority and sexual and gender minority youth and young adults by utilizing a national online survey and qualitative interviews to determine what factors influence testing attitudes with the goal of developing social marketing and text message health messaging interventions.

Project Title: Social and Behavioral Implications for COVID-19 Testing in Delaware's Underrepresented Communities
Awardee: Delaware State University
Project Number: 3P20GM103653-09S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will use retrospective data from the 2010 census and a Johns Hopkins University COVID-19 survey from the PHenX and DR2 repository to look at patterns of COVID-19 testing.

Project Title: Addressing Low-Income Housing Resident Mistrust in COVID-19 Guidance
Awardee: Eastern Virginia Medical School
Project Number: 3R37CA245716-01A1S1
Funding Opportunity Announcement: NOT-OD-20-119
Summary: This study will address distrust among low income housing residents towards public housing authorities (PHA) and determine how this impacts guidance and COVID-19 recommendations.

Project Title: RADx-UP CDCC
Awardee: Duke University
Project Number: 1U24MD016258-01
Funding Opportunity Announcement: RFA-OD-20-013
Summary: This study will bring together an interdisciplinary team comprising principal investigators with complementary expertise in clinical trial management, community engagement, data science and clinical research informatics to create a community-focused coordination and data collection center for RADx-UP.

RADx Tech/ATP

Project Title: A Rapid, Accurate, Disposable Molecular Diagnostic to detect SARS-CoV-2
Awardee: Visby Medical
Description: A palm-sized, single-use RT-PCR device that detects viral RNA with highly accurate results at the point-of-care in 30 minutes. The device was designed to be used by a person with minimal skills. This novel, versatile technology platform can also be adapted to provide simple, rapid tests for other diseases such as chlamydia, gonorrhea, and influenza.
Budget: $9,623,789
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: SARS-CoV-2 lab test accuracy within reach of every American with Liberty16 mobile real time PCR
Awardee: Ubiquitome
Description: A battery-operated, mobile RT-PCR device that detects viral RNA with high accuracy in 40 minutes and reports results via its proprietary iPhone app. It offers high throughput and could be much lower cost than lab-based RT-PCR tests. The device is targeted for use in rural and metropolitan hospitals and mobile labs.
Budget: $2,460,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Massively parallel centralized and decentralized ultrafast COVID-19 infectiousness testing
Awardee: Flambeau Diagnostics
Description: A lab module that can be deployed in a mobile van to screen asymptomatic individuals to detect SARS-CoV-2 at low viral levels in saliva samples, returning results in as little as one hour. The system can serve employers, schools, and underserved populations. It uses new extraction technology to purify and concentrate viral RNA reliably and quickly.
Budget: $12,000,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Ultra-Sensitive Immunoassay Test for Quantitation of SARS-CoV-2 Antigen
Awardee: Quanterix
Description: A laboratory antigen test with ultra-sensitive single-molecule immunoassay technology to enable detection from a variety of sample types including nasopharyngeal, saliva or self-acquired blood from a finger prick. Sample collection, transport, and processing will occur within 24-48 hours using existing sample collection logistics infrastructure through a network of centralized labs.
Budget: $18,200,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: A smartphone-based at-home self-test for rapid SARS-CoV-2 antigen detection from respiratory samples
Awardee: Luminostics, Inc.
Description: A rapid, smartphone-readout, antigen immunoassay that uses glow-in-the-dark nanomaterials to sensitively and specifically detect SARS-CoV-2 from shallow nasal swabs in 30 minutes or less, first for point-of-care use and later for home use.
Budget: $26,120,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: An innovative point-of-care COVID 19 antigen test for the direct detection of the SARS-CoV-2 virus
Awardee: Ellume USA LLC
Description: Two unique test cartridges contain a single-use, digital fluorescent immunoassay antigen test that returns accurate results in 15 minutes or less. One cartridge testing nasal swabs can be read out on two platforms by healthcare professionals, at the point of care or in laboratory settings for higher throughput. A second cartridge is being developed for home use with a self-administered nasal swab.
Budget: $29,950,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Rapid Expansion of Existing Framework for Deploying Large-Scale COVID-19 RT-PCR Testing Platforms and Distributing Capacities
Awardee: Sonic Healthcare USA
Description: Expanded scope and expedited timeline of a framework for large-scale COVID-19 RT-PCR testing platforms and distribution capacity. With a network of regional testing hubs, the company can simultaneously deploy multiple test platforms and methodologies. They will continue to add capacity to reach about 166,000 samples tested per day with new high-throughput technology.
Budget: $20,799,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: PathGroup SARS-CoV-2 High Throughput Laboratory Capacity Scale-Up
Awardee: PathGroup
Description: Uses Roche 6800 and Hologic Panther instruments to currently process about 10,000 COVID-19 RNA tests a day. Has infrastructure in place in 20 states throughout the U.S. Southeast and Midwest. They have partnered with ThermoFisher, LGC and Illumina to add additional instrumentation and automation to increase the daily number of COVID-19 tests performed to 80,000 by December 2020.
Budget: $20,750,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Illumina MegaLab: A Massively Scaled Next Generation Sequencing Lab For COVID-19 Testing in the U.S.
Awardee: Illumina, Inc.
Description: Automated sample processing and next-generation sequencing technology for COVID-19 testing that will be scaled up. Its high-throughput capacity can be expanded to 48,000 tests per day. Upon receipt of samples at the laboratory, the company can process results for the Illumina COVIDSeq test within 24 hours.
Budget: $12,398,342
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Nanotrap manufacturing scale-up to meet rapidly expanding needs for direct SARS-CoV-2 detection in high-throughput settings
Awardee: Ceres Nanosciences, Inc.
Description: A sample prep method using Nanotrap particles that extracts and concentrates viral material to reduce processing time and improve sensitivity. This method can be used on a variety of testing platforms, from point-of-care systems to high-throughput laboratory processes, to improve speed and performance by 2- to 10-fold.
Budget: $6,574,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Scaling the Broad Institute RT-PCR testing process to 100k+ tests/day
Awardee: Broad Institute
Description: A high-throughput RT-PCR COVID-19 viral test using specimens from nasal swabs that will be scaled up. Its facility already performs tests for more than 530 regional hospitals, nursing homes, shelters, community health centers, senior living facilities and at state and city collection sites in vulnerable communities. The award is helping to increase from 25,000 to 100,000 tests per day.
Budget: $14,584,482
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Aegis Sciences Rapid Development of SARS-CoV-2 Test Capacity
Awardee: Aegis Sciences
Description: A novel coronavirus nucleic acid detection kit and distribution system for high through-put testing that uses nasal and oral swab samples. Has recently quadrupled capacity to 15,000 samples per day and will soon reach 60,000 samples per day. After receipt of samples, these tests will return results in 24 hours or less on average. 
Budget: $6,582,976
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Accurate, Sensitive & Affordable POC and At Home Testing Device
Awardee: MicroGEM International
Description: A portable, point-of-care device that detects SARS-CoV-2 in saliva samples using RT-PCR in 15 minutes. The test uses a microfluidic cartridge with the potential for simultaneous detection of multiple pathogens such as influenza.
Budget: $40,928,479
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Maxim SARS-CoV-2 Antigen Rapid Test
Awardee: Maxim Biomedical, Inc.
Description: A single-use, lateral-flow test strip immunoassay that can provide results in 15 minutes or less. With the improved workflow, the assay can be performed without an instrument for reading and does not require any specialized equipment.
Budget: $5,253,450
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Deployment of a rapid, point of use technology for COVID-19 testing
Awardee: MatMaCorp
Description: A portable mini-lab that can rapidly perform multiple RT-PCR assays in a single platform. This technology can be used with multiple sources of reagents and is targeted for community hospitals and clinics in underserved, rural populations.
Budget: $1,390,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Rapid Manufacturing Scale-up for Compact Point-of-Care EUA SARS-CoV-2 RT-PCR Test
Awardee: Mesa Biotech, Inc.
Description: This test employs a hand-held RT-PCR device and a compact, single-use cartridge that detects viral RNA at the point of care. Results can be read from the removable cartridge in 30 minutes.
Budget: $18,536,704
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Talis-One/Talis HT: Highly Scalable SARS-CoV-2 RNA Detection in Minutes, from POC to Hundred-per-Hour Throughput
Awardee: Talis Biomedical Corp.
Description: This point of care test is a multiplexed cartridge used with the compact Talis One instrument. The test detects SARS-CoV-2 through isothermal amplification of viral RNA and an optical detection system, returning a result in under 30 minutes.
Budget: $25,400,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Manufacturing Capacity Scale-Up for Sofia SARS Antigen and Sofia Influenza A+B/SARS FIAs
Awardee: Quidel Corp.
Description: This test kit, a lateral flow immunoassay, is used with Sofia and Sofia 2 Analyzers in point of care settings, such as a doctor’s office or pharmacy. There are currently thousands of Quidel analyzers in place across the U.S. and HHS has identified this technology for nursing homes. The Analyzers give electronic results within 15 minutes.
Budget: $71,000,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Detection of SARS-CoV-2 with the CRISPR-based DETECTR platform
Awardee: Mammoth Biosciences
Description: This assay uses CRISPR technology, which provides a simpler workflow and significantly faster turnaround time compared to conventional laboratory PCR tests. This high-throughput solution can result in a multi-fold increase in testing capacity in commercial laboratories.
Budget: $23,081,269
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Scaling to Massive Throughput: 4.5 Million SARS-CoV-2 Tests per Day
Awardee: Fluidigm Corp.
Description: Each BioMark HD microfluidics platform has the capacity to process thousands of SARS-CoV-2 PCR tests per day with a primary focus on saliva samples. With many existing Fluidigm instruments in clinical and research labs throughout the U.S., scale up and deployment of their advanced integrated fluidic chips can provide tens to hundreds of thousands of new tests per day in fall 2020.
Budget: $36,834,000
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: Reproducible clinical test system for 1 million daily SARS-CoV-2 tests using amplicon sequencing
Awardee: Helix OpCo, LLC
Description: Helix will ship standardized kits in bulk for the collection of nasal swabs to public health departments, health care systems, employers and other customers to collect tens of thousands of samples and processed within 24-48 hours using sophisticated automation processes and next generation sequencing technologies. Expected to process up to 50,000 samples/day by Sept. 2020 and 100,000/day by year’s end.
Budget: $33,421,500
Additional Information: RADx Tech/ATP Phase 2 Awards

Project Title: RADx-ATP Concentric: A High-Throughput Next Generation Sequencing-based Molecular Diagnostic for SARS-CoV-2
Awardee: Ginkgo Bioworks
Description: Ginkgo is scaling up by using significant automation and next-generation sequencing technologies to process tens of thousands of tests at once. Working with universities, schools, public or private companies, and local communities, they will provide end-to-end sample collection and report results within 24-48 hours. Expected to scale up to 50,000 tests/day in Sept. 2020 and 100,000/day by year’s end.
Budget: $40,473,832
Additional Information: RADx Tech/ATP Phase 2 Awards

Closed Funding Opportunities

RADxSM Underserved Populations (RADx-UP)

Notice: Emergency Awards: RADx-UP Coordination and Data Collection Center (CDCC) (U24 Clinical Trial Optional)
Notice Number: RFA-OD-20-013
Post Date: June 12, 2020
Application Due Date(s): August 7, 2020
Expiration Date: August 8, 2020
Additional Information:

Notice: Notice of Special Interest (NOSI): Limited Competition for Emergency Competitive Revisions for Community-Engaged Research on COVID-19 Testing among Underserved and/or Vulnerable Populations
Notice Number: NOT-OD-20-121
Post Date: June 12, 2020
Application Due Date(s): August 7, 2020
Expiration Date: August 8, 2020
Additional Information:

Notice: Notice of Special Interest (NOSI): Emergency Competitive Revisions for Community-Engaged Research on COVID-19 Testing among Underserved and/or Vulnerable Populations
Notice Number: NOT-OD-20-120
Post Date: June 12, 2020
Application Due Date(s): August 7, 2020; September 8, 2020
Expiration Date: September 9, 2020
Additional Information:

Notice: Notice of Special Interest (NOSI): Emergency Competitive Revisions for Social, Ethical, and Behavioral Implications (SEBI) Research on COVID-19 Testing among Underserved and/or Vulnerable Populations
Notice Number: NOT-OD-20-119
Post Date: June 12, 2020
Application Due Date(s): August 7, 2020; September 8, 2020
Expiration Date: September 9, 2020
Additional Information:

RADxSM Radical (RADx-rad)

Notice: Notice of Special Interest (NOSI): Availability of Emergency Competitive Revisions for Wastewater Surveillance Research for Public Health Response to Coronavirus Disease 2019 (COVID-19)
Notice Number: NOT-OD-20-159
Post Date: August 6, 2020
Application Due Date(s): August 21, 2020
Expiration Date: August 22, 2020

Notice: Availability of Emergency Competitive Revisions for Chemosensory Testing as a COVID-19 Screening Tool
Notice Number: NOT-OD-20-152
Post Date: August 6, 2020
Application Due Date(s): September 15, 2020
Expiration Date: September 16, 2020

Notice: Emergency Awards: Automatic Detection and Tracing of SARS-CoV-2 (U01 Clinical Trial Not Allowed)
Notice Number: RFA-OD-20-014​
Post Date: August 6, 2020
Application Due Date(s): September 15, 2020
Expiration Date: September 16, 2020

Notice: Emergency Awards: RADx-rad Wastewater Detection of SARS-COV-2 (COVID-19) (U01 - Clinical Trials Not Allowed)
Notice Number: RFA-OD-20-015
Post Date: August 6, 2020
Application Due Date(s): September 15, 2020
Expiration Date: September 16, 2020

Notice: Emergency Awards: Chemosensory Testing as a COVID-19 Screening Tool (U01 Clinical Trial Optional)
Notice Number: RFA-OD-20-022
Post Date: August 6, 2020
Application Due Date(s): September 15, 2020
Expiration Date: September 16, 2020

Notice: Emergency Awards RADx-RAD: Screening for COVID-19 by Electronic-Nose Technology (SCENT) (U18 Clinical Trial Not Allowed)
Notice Number: RFA-OD-20-017
Post Date: August 6, 2020
Application Due Date(s): September 18, 2020
Expiration Date: September 19, 2020

Notice: Emergency Awards: Exosome-based Non-traditional Technologies Towards Multi-Parametric and Integrated Approaches for SARS-CoV-2 (U18 Clinical Trial Not Allowed)
Notice Number: RFA-OD-20-018
Post Date: August 6, 2020
Application Due Date(s): September 18, 2020
Expiration Date: September 19, 2020

Notice: Emergency Awards RADx-RAD: Novel Biosensing for Screening, Diagnosis and Monitoring of COVID-19 From Skin and The Oral Cavity (R44 Clinical Trial Not Allowed)
Notice Number: RFA-OD-20-020
Post Date: August 6, 2020
Application Due Date(s): September 18, 2020
Expiration Date: September 19, 2020

Notice: Emergency Awards RADx-RAD: Novel Biosensing for Screening, Diagnosis and Monitoring of COVID-19 From Skin and The Oral Cavity (Fast-Track STTR Clinical Trial Not Allowed)
Notice Number: RFA-OD-20-021
Post Date: August 6, 2020
Application Due Date(s): September 18, 2020
Expiration Date: September 19, 2020

Notice: Emergency Awards: RADx-RAD Multimodal COVID-19 surveillance methods for high risk clustered populations (R01 Clinical Trial Optional)
Notice Number: RFA-OD-20-016​
Post Date: August 6, 2020
Application Due Date(s): September 30, 2020
Expiration Date: October 1, 2020

Notice: Emergency Awards: RADx-rad Data Coordination Center (DCC) (U24 Clinical Trial Not Allowed)
Notice Number: RFA-OD-20-019
Post Date: August 6, 2020
Application Due Date(s): September 30, 2020
Expiration Date: October 1, 2020

Notice: Emergency Awards: RADx-rad Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence (PreVAIL kIds) (R61/R33 Clinical Trial Optional)
Notice Number: RFA-OD-20-023
Post Date: August 6, 2020
Application Due Date(s): September 30, 2020
Expiration Date: October 1, 2020

Notice: Notice of Intent to Publish Funding Opportunity Announcements for the RADx-rad Initiative
Notice Number: NOT-OD-20-144
Post Date: July 10, 2020

This page last reviewed on November 23, 2020