NIH Research Matters
May 18, 2015
An experimental therapy for an inherited disorder that causes blindness improves vision, but the improvement declines with time. The findings offer insights for future therapies.
A new resource allows scientists to examine how genomic differences affect gene activity in tissues and organs across the body—and how that activity influences susceptibility to diseases such as cancer, heart disease, and diabetes.
Researchers developed a tool that can turn specific sets of neurons on and off in mice to affect behavior. The technology can help scientists study mental health and disorders.
May 4, 2015
A newly designed agent was effective in treating monkeys infected with a deadly Ebola virus strain. The therapy is now being tested in Sierra Leone in people infected with Ebola.
Two devices, developed independently, can gauge how tumors respond to various drugs. With further development, they could help determine ideal individual treatments.
Scientists revealed the molecular structure of a key target for blood pressure medications. The findings may aid the development of blood pressure drugs with fewer side effects.
April 27, 2015
Among patients undergoing complex cardiac surgeries, a clinical study found no advantage to only transfusing red blood cells stored for shorter periods of time.
Researchers mapped different language impairments to specific brain regions to reveal the basic organization of our language system.
In a mouse study, 2 drugs already on the market activated stem cells and repaired the type of brain damage seen in multiple sclerosis. The finding might lead to novel therapies.
April 20, 2015
An experimental antibody significantly reduced HIV levels in infected people for as long as 28 days. The approach might help to combat a wide range of HIV strains.
A common over-the-counter allergy drug lowered hepatitis C virus levels in infected mice. The drug is currently being tested in patients with chronic hepatitis C.
A structural study revealed how an antibiotic called borrelidin stops bacterial growth. The findings may help researchers design improved drugs to fight infections.
April 13, 2015
An experimental Ebola vaccine called VSV-ZEBOV was safe and produced robust antibody responses in all the healthy adults who received it. Itís now being tested in Liberia.
Using an advanced genetic test, researchers detected diffuse large B-cell lymphoma in blood before it could be seen on CT scans. The technique could improve disease monitoring.
Researchers identified beige fat cells, which burn energy rather than store it, in humans. The finding may lead to new ways to engineer fat cells to fight obesity.
March 30, 2015
Researchers used a tetanus booster to enhance the effects of an experimental immunotherapy against glioblastoma, a deadly type of brain cancer.
Pathologists asked to interpret a difficult set of breast biopsy slides accurately made most diagnoses, but the results suggest strategies for future improvement.
Mice with immune cells unable to use vitamin D developed precursors of heart disease and type 2 diabetes. The mechanisms uncovered may lead to novel therapies.
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About NIH Research Matters
Editor: Harrison Wein, Ph.D.
Assistant Editors: Vicki Contie, Carol Torgan, Ph.D.
NIH Research Matters is a weekly update of NIH research highlights from the Office of Communications and Public Liaison, Office of the Director, National Institutes of Health.