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Thursday, December 8, 2022
Canine brain wiring influenced by human-driven breeding practices
NIH findings may help researchers understand how genomic variation can affect behavioral differences in humans.
National Institutes of Health researchers have shown that areas of the genome related to brain development harbor variants that may account for behavioral differences among different dog lineages. The study, funded by the National Human Genome Research Institute (NHGRI) and published in the journal Cell, involved citizen science projects that used DNA samples and surveys collected from dog owners around the world.
The researchers found that the genomic differences among dog breeds are related to the development of their nervous system. For dogs that herd sheep, the genomic differences involve how brain nerve cells, known as neurons, organize themselves to form neural circuits during the early stages of development.
Some of the genes associated with the different dog lineages may relate to genes that are involved in behavior of other species such as humans. These results suggest that dogs and humans may have similar biological pathways that give rise to the range of differences in brain function and behavior found within a species.
“The results of this study may point us toward how differences in the human genome can contribute to behavioral diversity among humans. Further research can help us draw a stronger link between genes that are important for behavior in dogs and genes that may play a role in human behavioral conditions,” said said Elaine Ostrander, Ph.D., distinguished senior investigator and chief of the Cancer Genetics and Comparative Genomics Branch within NHGRI’s Intramural Research Program and corresponding author on the study.
The study, led by Emily Dutrow, Ph.D., a postdoctoral research fellow in Dr. Ostrander’s group, first mapped out the diversification of dog lineages over time. They used genomic data from over 4,000 domestic, semi-feral and wild dogs collected from various available data sets. These data sets included results of whole-genome sequencing, which analyzes the entire genome, and single-nucleotide polymorphism arrays, which detect a subset of the variation in a genome. The researchers also used behavioral data from a University of Pennsylvania School of Veterinary Medicine, Philadelphia, survey of over 46,000 dogs that assessed characteristics such as trainability, energy and fear towards strangers.
“We identified 10 major canine lineages and behavioral traits that correlate with these lineages. By looking at the most heavily selected breeds, we can see how each lineage of dog breeds is unique in its genomic variation and behavior,” said Elaine Ostrander, Ph.D., distinguished senior investigator and chief of the Cancer Genetics and Comparative Genomics Branch within NHGRI’s Intramural Research Program and corresponding author on the study.
“One of the most surprising findings was that many of the genomic changes that define the major dog lineages can also be found in modern wolves. This indicates that humans co-opted ancient variations among wild ancestors of dogs to create unique types of dogs suited for performing specific tasks,” said Dr. Dutrow.
For thousands of years, selective breeding has shaped dog breeds that are specialized for different tasks, including hunting, herding and guarding. For example, sheepdogs (such as border collies) instinctively know how to herd livestock with minimal training.
How different dog breeds have distinct behavioral traits and personalities — and how these characteristics trace back to their genomes — have been largely unknown until now.
The challenge was parsing out the massive collections of data. By repurposing tools used in studies that, for example, examine how stem cells develop into different specialized cells, the researchers reconstructed how canine lineages developed.
“To study the genomic basis of breeds, researchers typically compare different breeds with different behavior. But the difficulty with that is finding meaningful results among the variation in dog behavior,” said Dr. Ostrander. “Instead of looking at a snapshot in time, our study mapped out how dog breed lineages diversified over hundreds of years and explains how the different breeds we see today are a result of human selection.”
The National Human Genome Research Institute (NHGRI) is one of the 27 institutes and centers at the NIH, an agency of the Department of Health and Human Services. The NHGRI Division of Intramural Research develops and implements technology to understand, diagnose and treat genomic and genetic diseases. Additional information about NHGRI can be found at: www.genome.gov.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
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