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20141208-DNA.jpg
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Damaged DNA
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Credit
Bret Freudenthal, NIEHS
Description
After the DNA polymerase (gray molecule in background) inserts a damaged nucleotide into DNA, the damaged nucleotide is unable to bond with its undamaged partner. As a result, the damaged nucleotide swings freely within the DNA, interfering with the repair function or causing double-strand breaks. These steps may ultimately lead to several human diseases.
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Damaged DNA.