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Illustration of parallel AmB molecules with many sterols bound to them and others rising from the cell membrane below.

Media Folder

2023

Title

Illustration of parallel AmB molecules with many sterols bound to them and others rising from the cell membrane below.

Caption

AmB (blue) molecules form a molecular “sponge” that captures sterols like cholesterol and ergosterol (dotted) from cell membranes. This atomic level understanding of how it works yielded a breakthrough kidney-sparing antifungal agent.

Credit

Jose Vazquez, University of Illinois

Description

Illustration of parallel AmB molecules with many sterols bound to them and others rising from the cell membrane below.
OD

Site_Section

NIH Research Matters

Alt Text

Illustration of parallel AmB molecules with many sterols bound to them and others rising from the cell membrane below.