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Tuesday, March 16, 2010
Bench to Bassinet Program Seeks Congenital Heart Disease Treatments
Efforts Aim to Move Lab Results into Clinical Practice.
To help speed the translation of scientific discoveries into usable treatments in congenital heart disease, the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health launched the Bench to Bassinet Program (http://www.benchtobassinet.net/). This program, which involves several major research institutions across the country, will be highlighted in the March 23 edition of the Journal of the American College of Cardiology. Congenital heart disease affects the lives of 40,000 newborns a year in the United States, and up to 2 million adults are living with congenital heart disease.
The Bench to Bassinet Program consists of three major research efforts. The two newest, highlighted in the journal article, are the Pediatric Cardiac Genomic Consortium and the Cardiovascular Development Consortium. The Bench to Bassinet Program also coordinates with the NHLBI-funded Pediatric Heart Network (http://www.pediatricheartnetwork.com/), a group of academic institutions in the United States and Canada conducting research to determine optimal therapies for children with congenital and acquired heart disease. New England Research Institutes serves as the coordinating center for the overall program.
Investigators in the Pediatric Cardiac Genomics Consortium will search the human genome for genetic defects that lead to heart problems. The participating research centers will study genetic data from hundreds of individuals born with congenital heart disease to uncover genes that may cause congenital heart disease, and how those genes influence the outcome of therapy. The institutes conducting this research are: The Children’s Hospital Boston and the Brigham and Women’s Hospital, Mass.; The Children’s Hospital of Philadelphia, Pa. ; Columbia University Health Science, New York City; the Mount Sinai School of Medicine, New York City; and Yale University, New Haven, Conn.
Researchers still have many questions about the various complex pathways that lead to the creation of a healthy heart. Advances in technology and recent research findings make this an opportune time to launch an intensive collaboration designed to provide a comprehensive picture of the key steps in the development of healthy and abnormal hearts. Teams in the Cardiovascular Development Consortium will offer vital insights into heart development. The research institutes are: the J. David Gladstone Institutes, San Francisco, Calif.; Harvard University Medical School, Boston, Mass; the University of Pittsburgh, Pa.; and the University of Utah, Salt Lake City.
These two new programs, along with the Pediatric Heart Network, provide the framework to move fundamental knowledge rapidly into clinical practice, and to use insights from clinical practice to inform basic and genetic research.
Gail Pearson, M.D., Sc.D., chief of the Heart Development and Structural Diseases Branch, and director of the Adult and Pediatric Cardiac Research Program in the NHLBI’s Division of Cardiovascular Sciences, is available to comment on the significance and goals of the Bench to Bassinet Program.
To schedule interviews, contact the NHLBI Communications Office at 301-496-4236 or firstname.lastname@example.org.
The National Heart, Lung, and Blood Institute (NHLBI) plans, conducts, and supports research related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases; and sleep disorders. The Institute also administers national health education campaigns on women and heart disease, healthy weight for children, and other topics. NHLBI press releases and other materials are available online at: www.nhlbi.nih.gov.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
NIH…Turning Discovery Into Health®
NHLBI Diseases and Conditions Index
Congenital Heart Defects: http://www.nhlbi.nih.gov/health/dci/Diseases/chd/chd_what.html
Bench to Bassinet
Program Overview: http://www.benchtobassinet.net/
Pediatric Heart Network
Program Overview: http://www.pediatricheartnetwork.com/
At the request of the Institute, on March 17, in the sub-headline, the corrected text "Efforts Aim" replaced the text "Multi-institutional Effort Aims."
In the first paragraph, 3rd line, the corrected text "of Health launched" replaced the text "of Health recently launched."
In the second paragraph, 3rd line, the sentence "The Bench to Bassinet Program also coordinates with the NHLBI-funded Pediatric Heart Network (http://www.pediatricheartnetwork.com/), a group of academic institutions in the United States and Canada conducting research to determine optimal therapies for children with congenital and acquired heart disease" was added.
In the second paragraph, 6th line the corrected text "New England Research" replaced the text "The New England Research."
In the third paragraph, 1st line, the corrected text "Pediatric Cardiac Genomics Consortium" replaced the text "Pediatric Cardiac Genomics Program."
In the fourth paragraph, 5th line, the corrected text "Development Consortium will offer" replaced the text “Development Consortium will use state-of-the-art techniques to offer."
In the fifth paragraph, 1st line, the corrected text, "along with the Pediatric Heart Network" replaced the text, "align with the NHLBI-funded Pediatric Heart Network (http://www.pediatricheartnetwork.com/), a group of academic institutions in the United States and Canada conducting research to determine optimal therapies for children with congenital and acquired heart disease. Together, these three research efforts."
In the sixth paragraph, 4th line, the corrected text "Bench to Bassinet Program" replaced the text "Bench to Bassinet Project."