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Media Advisory
Thursday, May 16, 2019
Human antibody reveals hidden vulnerability in influenza virus
Discovery by NIAID-funded researchers could aid quest for universal flu vaccine.
What
The ever-changing “head” of an influenza virus protein has an unexpected Achilles heel, report scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health. The team discovered and characterized the structure of a naturally occurring human antibody that recognizes and disrupts a portion of the hemagglutinin (HA) protein that the virus uses to enter and infect cells. The investigators determined that the antibody, FluA-20, binds tightly to an area on the globular head of the HA protein that is only very briefly accessible to antibody attack. The site was not expected to be vulnerable to such a strike.
James E. Crowe, Jr., M.D., of Vanderbilt University Medical Center, Nashville, Tennessee, and Ian A. Wilson, D. Phil., of The Scripps Research Institute, San Diego, California, led the team. They isolated FluA-20 antibody from a person who had received many influenza immunizations. In a series of experiments, they showed that FluA-20 can “reach into” an otherwise inaccessible part of the three-part HA trimer molecule and cause it to fall apart, thus preventing the spread of virus from cell to cell. This discovery came as a surprise because this region of trimeric HA was thought to be stable and inaccessible to antibodies. Moreover, this region — unlike the rest of HA’s head — varies little from strain to strain. In theory, antibody-based therapeutics directed at that precise region would be effective against many strains of influenza A virus. Similarly, vaccines designed to elicit antibodies against this target might provide long-lasting protection against any influenza strain, potentially eliminating the need for annual seasonal influenza vaccination.
In mouse studies, FluA-20 prevented infection or illness when the animals were exposed to four different influenza A viral subtypes that cause disease in humans. Two viruses used in the experiments, H1N1 and H5N1, are Group 1 influenza subtypes, while the two others, H3N2 and H7N9, are members of Group 2. Current influenza vaccines must contain viral components from both subtypes to elicit matching antibodies. A single vaccine able to generate potent antibodies against members of both groups could provide broad multi-year protection against influenza.
Article
S Bangaru et al. A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface. Cell DOI: 10.1016/j.cell.2019.04.011 (2019).
Who
NIAID Director Anthony S. Fauci, M.D., is available to discuss this research.
Contact
To schedule interviews, please contact Anne A. Oplinger, (301) 402-1663, aoplinger@niaid.nih.gov.
This research was funded, in part, by NIH grants U19 AI117905, R56 AI127371 and P01 AI097092 from NIAID, P41 GM103393 from the National Institute of General Medical Sciences and UL1 TR002243 from the National Center for Advancing Translational Sciences, as well as by NIH contracts HHSN272201400024C, HHSN272201400008C and HHSN27220170041I.
This media availability describes basic research. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process — each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.
NIAID conducts and supports research — at NIH, throughout the United States, and worldwide — to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.
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