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Tuesday, July 15, 2008
Research Uncovers Little-Known Impacts of Smell and Taste on Health
NIDCD-Supported Science to be Presented at International Chemical Senses Symposium in San Francisco
What: The senses of smell and taste may have greater bearing on health than is generally accepted by both doctors and patients. Recent research suggests that these senses and their influence on behavior have implications for nutrition, aging, mental health, obesity, diabetes and safety. Researchers supported by the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health, will be presenting their work at the International Symposium on Olfaction and Taste.
When: July 21-26, 2008
Where: Hyatt Regency Hotel at the Embarcadero, San Francisco
Additional Information: Read on for a sampling of topics to be covered at the meeting.
Epidemiological Studies of Taste and Smell
Scientists who study smell and taste are uncovering evidence that these senses make surprising contributions to our overall health. Genetic variations and smell and taste disorders may underlie dietary habits and impact weight, blood pressure and other risk factors for cardiovascular disease or diabetes. However, epidemiologists have conducted few studies to measure the prevalence and types of smell and taste disorders in the general population or among various age groups. In this symposium, NIDCD epidemiologist Howard Hoffman will describe NIH efforts to encourage improved collection of statistical data on normal and disordered smell and taste. Among the other symposium speakers will be NIDCD-supported scientists Claire Murphy, Ph.D., of San Diego State University, who studies smell and the aging brain; Linda Bartoshuk, Ph.D., of the University of Florida, an internationally recognized taste researcher; and Karen Cruickshanks, Ph.D., of the University of Wisconsin, who leads population studies in Beaver Dam, Wisc. (Saturday, July 26, Symposium, 9:00 to 11:15 a.m., Grand Ballroom C)
Edible Taste Strips Could Standardize Taste Testing
In order to accurately measure normal ranges of taste sensitivity by gender and age, scientists need a standardized, validated taste test. Researchers currently use various tests, each with specific limitations, in which participants rate the intensity of a taste in a liquid, flavored candy or on filter paper. NIDCD-funded researchers Gregory Smutzer, Ph.D., of Temple University in Philadelphia, and Lloyd Hastings, Ph.D., of Osmic Enterprises Inc. in Cincinnati, are leading the development of edible taste strips that could improve accuracy and ease the administration of taste tests. Smutzer and his team have created taste strips, similar to breath-freshening strips, each containing a precise amount of a chemical taste stimulus. The researchers can prepare these strips to measure salt, sweet, sour, bitter and savory (also known as umami) taste sensitivity. (Friday, July 25, Poster Session IV, 2:00 to 6:00 p.m., Pacific Concourse, Posters #349, 351 and 352)
How Sweet It Is
From the donut counter to our ever-expanding waistlines, scientists are seeking clues about what could be driving the obesity epidemic in America. While much of the research effort is focused on how the body uses and stores energy, NIDCD-supported research is uncovering valuable clues through studies on the sense of taste. Studies on sweet taste receptors are providing new evidence for biological factors that raise or lower sensitivity to sweet tastes and might stoke desire for cookies, cake, ice cream and other sweet treats. In this symposium, Steven Munger, Ph.D., of the University of Maryland School of Medicine, will present recent findings on a hormone known as glucagon-like peptide-1 (GLP-1) that appears to modulate sensitivity to sweet tastes. Scientists already knew that GLP-1 produced in the gut stimulates insulin production. Munger and his collaborators from NIH's National Institute on Aging demonstrated that GLP-1 is also made in taste buds and appears to act on taste cells to maintain or enhance sweet taste sensitivity. This discovery suggests that interventions aimed at the taste buds might be able to dull sweet cravings. (Thursday, July 24, Symposium, 8:00 to 10:15 a.m., Grand Ballroom A)
From Bitter to Sweet, It's in Our Genes
Scientists hypothesize that bitter taste receptors evolved to prevent early humans from ingesting bitter-tasting toxins commonly found in plants. Yet, in scientific taste tests, up to 30 percent of people barely recognize some bitter tastes while others seem to have a heightened sensitivity to them. Bitterness can enhance food flavor—coffee, bok choy, dark chocolate and beer are perennial favorites for this reason. Scientists are seeking to better understand our response to bitterness and its influence on diet and nutrition. In this symposium, NIDCD researcher Dennis Drayna, Ph.D., will discuss genetic studies that are helping to explain why people respond differently to bitter as well as sweet-tasting compounds. His group previously identified a gene that explains differences in bitter taste perception, and has now expanded his genetic studies to understand the range of sweet taste perception. He and his team have pinpointed genetic differences that affect sweet sensitivity in different populations. Understanding such differences could help public health officials to more effectively foster healthy eating in global populations. (Wednesday, July 23, Symposium, 8:00 to 10:15 a.m., Grand Ballroom C)
When Chronic Sinusitis Impairs Smell
A glance down the sinus remedy aisle of your local drug store only hints at the impact of chronic sinusitis in the United States. More than 30 million Americans have chronic sinusitis, according to the Centers for Disease Control and Prevention. In addition to its vexing upper respiratory symptoms, chronic sinusitis often also diminishes the sense of smell (and, thus, flavor perception). In spite of the health consequences of this widespread condition, treatment options are limited and often ineffective. This symposium will cover several studies including clinical measurements at Monell Chemical Senses Center and Thomas Jefferson University. NIDCD-funded researchers there, led by Monell's Nancy Rawson, Ph.D., and Beverly Cowart, Ph.D., are examining people with chronic sinusitis and measuring key characteristics of their disease. These studies are expected to provide valuable insights on factors of chronic sinusitis that erode the sense of smell. (Tuesday, July 22, Symposium, 7:00 to 9:15 p.m., Grand Ballroom B, and Friday, July 25, Poster Session IV, 2:00 to 6:00 p.m., Pacific Concourse, Poster #385)
Helping Firefighters Preserve their Sense of Smell
Firefighters know they are putting theirs lives on the line when they rush into a burning building, but may not be aware of the potential risk to their sense of smell. Researchers led by Pamela Dalton, Ph.D., at the Monell Chemical Senses Center studied Philadelphia firefighters with varying years of experience and found that reduced sense of smell was associated with greater years of employment. Firefighters often do not know which chemicals might be present in a fire and are regularly exposed to a variety of chemical gases and fumes. Loss of smell will not only reduce a firefighter's quality of life, but also represents an occupational hazard as it may diminish his or her ability to smell smoke or burning wires. The NIDCD-funded researchers say their results illustrate the importance of using protective respiratory devices and monitoring firefighters' sense of smell. They also are conducting a long-term study of new firefighter recruits. (Wednesday, July 23, Poster Session II, 2:00 to 6:00 p.m., Pacific Concourse, Poster #169)
For more information on the International Symposium on Olfaction and Taste, visit www.achems.org.
NIDCD, which celebrates its 20th anniversary in 2008, supports and conducts research and research training on the normal and disordered processes of hearing, balance, smell, taste, voice, speech and language and provides health information, based upon scientific discovery, to the public. For more information about NIDCD programs, see the Web site at www.nidcd.nih.gov.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
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