NIH-Funded ACTIV/ACTIV-Associated Clinical Trials

Company Therapeutic Class Administration New/
Repurposed		 Estimated
End Date

ACTIV-1 Inpatient
BMS Orencia® (abatacept) Immune Modulator Intravenous Repurposed Q4 2021
Janssen Remicade® (Infliximab) Immune Modulator Intravenous Repurposed Q4 2021
AbbVie Cenicriviroc Immune Modulator Oral New Q4 2021

ACTIV-2 Outpatient
AstraZeneca AZD7442 Monoclonal Antibody Cocktail Intramuscular New Q4 2021
AstraZeneca AZD7442 Monoclonal Antibody Cocktail Intravenous New Q4 2021
Brii Biosciences Brii-196 & Brii-198 Monoclonal Antibody Cocktail Intravenous New Q4 2021
Eli Lilly LY-CoV-555 Monoclonal Antibody Single Intravenous New Q1 2021
Sagent Camostat Mesylate Antiviral Oral Repurposed Q4 2021
Synairgen SNG001 IFN-beta Immune Modulator Inhaled Repurposed Q4 2021

ACTIV-3 Inpatient
AstraZeneca AZD7442 Monoclonal Antibody Cocktail Intravenous New Q3 2021
Brii Biosciences Brii-196 & Brii-198 Monoclonal Antibody Cocktail Intravenous New Ended
Eli Lilly LY-CoV-555 Monoclonal Antibody Single Intravenous New Ended
GSK-Vir VIR-7831 Monoclonal Antibody Single Intravenous New Ended

ACTIV-4

Outpatients
BMS/Pfizer Eliquis ® (apixaban) Anticoagulant Oral Repurposed Q4 2021
BMS/Pfizer Aspirin Antiplatelet Oral Repurposed Q4 2021

Inpatients
Other Un-fractionated (UF) Heparin Anticoagulant Intravenous Repurposed Q2 2021
Other Low Molecular Weight (LMW) Heparin Anticoagulant Injection Repurposed Q2 2021

ACTIV-5 Inpatient
AbbVie/Boehringer Ingelheim SkyrisiTM (risankizumab) Immune Modulator Intravenous Repurposed Q4 2021
Humanigen Lenzilumab Immune Modulator Intravenous New Q4 2021

ACTIV-Associated

Adaptive COVID-19 Treatment Trial (ACTT) Inpatient
Gilead Veklury® (remdesivir) Antiviral Intravenous Repurposed Q4 2020
Gilead/Eli Lilly Veklury® (remdesivir) and Olumiant® (baricitinib) Antiviral/Anti-Inflammatory Intravenous/Oral Repurposed Q4 2020
Gilead/Eli Lilly/Other Veklury® (remdesivir) and Olumiant® (baricitinib) or Dexamethasone Antiviral/Anti-Inflammatory/
Immune Modulator		 Intravenous/Oral Repurposed Q2 2021
Gilead/Merck KGaA Veklury® (remdesivir) and Rebif® (IFN-beta ) Antiviral/Immune Modulator Injection Repurposed Q1 2021

Inpatient Treatment with Anti-Coronavirus Immunoglobulin (ITAC)
Gilead/Other Veklury® (remdesivir) and Hyperimmune
Intravenous Immunoglobulin (hIVIG)		 Antiviral Intravenous N/A Q3 2021

Convalescent Plasma in Outpatients with COVID-19 (C3PO)

Other Convalescent Plasma Convalescent Plasma Intravenous N/A Ended

Convalescent Plasma to Limit COVID-19 Complications in Hospitalized Patients (CONTAIN COVID-19)
Other Convalescent Plasma Convalescent Plasma Intravenous N/A Q2 2021

Passive Immunity Trial of Our Nation (PassItOn) Inpatient
Other Convalescent Plasma Convalescent Plasma Intravenous N/A Q2 2021

This page last reviewed on March 4, 2021