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The Lasker Scholars program provides a unique opportunity for clinician-scientists to receive a combination of intramural and extramural NIH research support.
The program has two phases. The first phase will support scholars in the IRP for 5 years, with the possibility of an extension of this phase for an additional 2 years. Lasker Scholars will be appointed as independent tenure-track investigators within an NIH Institute or Center, a process that includes being hired as a full time employee at the NIH and completing the procedures required of new Federal government employees. The IRP will provide space, research expenses, full salary, and Federal employee benefits. Scholars will develop independent research activities over the course of their stay in the IRP, and will be formally reviewed by a panel of senior extramural investigators every 2 to 4 years to evaluate their research progress.
Upon successfully completing the initial IRP phase of the program, the Lasker Scholar will be eligible for two options in the second phase:
Option 1. Remain in the IRP with continued intramural funding and progression to tenured senior investigator status after appropriate assessment. Retention in the IRP will be dependent on the development of a mutual agreement between the Scholar and the IRP. Tenure at the NIH requires evaluation and approval by the NIH Deputy Director for Intramural Research.
Option 2. The Scholar can receive up to 3 years of support to continue independent research at an extramural sponsoring institution. This support is contingent upon obtaining an appropriate extramural position at an eligible institution, and the successful NIH programmatic review of the scholar’s progress during the intramural phase of the award. Lasker Scholars can request direct costs of up to $499,000/year (plus applicable indirect costs). Scholars must complete 5 years of research in the IRP to be eligible for the extramural Lasker Scholars Grant.
Research Areas of Interest
The Intramural Research Program will give highest priority to those applications which propose research within the fields given below, listed by participating Institutes/Centers. Applicants are strongly advised to contact the Institute/Center scientific contact person listed in the Program Announcement, to obtain feedback regarding the programmatic appropriateness of their research to the goals of the NIH intramural research program.
National Cancer Institute:
- Medical oncology, pediatric hematology-oncology, radiation oncology, surgical oncology, pathology, neuro-oncology, urology and dermatology. Specific areas within these categories include genitourinary oncology, lymphoid malignancies, neuro-oncology, immunotherapy (including cell therapy and transplant), women's cancers, aeoro-digestive cancers, molecular diagnostics, and functional imaging.
- Translational and clinical epidemiology, genetics of cancer
National Eye Institute:
- Neurodegenerative eye disease, neuro-immunology and immunometabolism
National Heart, Lung, and Blood Institute:
- Cardiovascular, blood, and pulmonary research
- Pediatric and developmental biology
- Cardiovascular research: heart failure, non-surgical interventional therapeutics, cardiovascular imaging, inflammation and cardiovascular disease, pulmonary hypertension, dyslipidemias, disease discovery research.
- Blood research: myeloproliferative disorders, benign hematology, bone marrow failure syndromes, myelodysplastic syndromes, acute and chronic leukemias and other hematological malignancies, hematopoietic stem cell transplantation, cell based therapies to treat GVHD, malignancies, viral diseases, and bone marrow failure
- Pulmonary research: pulmonary interstitial disease, pulmonary hypertension, airway inflammation and asthma, host defense mechanisms, rare lung disease, pulmonary nontubercular mycobacterial disease.
- Sickle cell research, gene therapy for sickle cell disease, novel therapeutics to prevent and treat vaso-occlusive crisis.
- Cell therapy based treatments for tumors utilizing NK cells, T-cells, hematopoietic stem cells, and iPS cells.
- Regenerative medicine utilizing iPSCs
- Population Sciences Research
National Human Genome Research Institute:
- Genomic medicine focus; improving the effectiveness of health care including developing innovative approaches to incorporate genomic data into electronic health records (EHRs), demonstrating effectiveness and clinical utility of genomic information across diverse populations, and increasing access to genomic information across heterogeneous healthcare systems.
- Improving how genomic data is interpreted to facilitate the return of information to clinicians and patients.
National Institute of Allergy and Infectious Diseases:
- Clinical allergy/immunology; clinical infectious diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development:
- Developmental bone disorders
- Pediatric endocrinology
- Reproductive medicine
- Genetic disorders affecting human development
- Pediatric metabolic disorders
- Women's health research
- Maternal fetal medicine
National Institute of Dental and Craniofacial Research:
- Craniofacial anomalies, including genetics, pathophysiology, and surgical therapies
- Craniofacial regenerative medicine, tissue engineering, stem cell biology
- Craniofacial and dental developmental biology and human genetics
- Metabolic bone disease
National Institute of Diabetes and Digestive and Kidney Diseases:
National Institute of Environmental Health Sciences:
- Metabolic diseases
- Reproductive - puberty, estrogen effects, menopause
- Women's health including bone health
- Pulmonary diseases
- Human genetics
- Environmental exposures
- Health disparities
National Institute of Mental Health:
- Psychosis - underlying neurobiological mechanisms, pathophysiology and potential therapeutics.
National Institute on Minority Health and Health Disparities:
- Multidisciplinary studies of minority health and health disparities
- Interactions between socioeconomic factors and race/ethnicity and their effects on health outcomes
- Social and behavioral determinants of minority health and health disparities
- The interaction of genetic, biological, social and behavioral factors in shaping disparities in risk factors, protective factors, and health outcomes.
National Institute of Nursing Research
- Symptom science/biology within a clinical context
This page last reviewed on April 1, 2019